Back to Search
Start Over
Spherical mesoporous Fe-N-C single-atom nanozyme for photothermal and catalytic synergistic antibacterial therapy
- Source :
- Journal of Colloid and Interface Science. 606:826-836
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Nanozyme has been regarded as an efficient antibiotic to kill bacteria using the reactive oxygen species (ROS) generated by Fenton-like reaction. However, its activity is still unsatisfied and requires large amount of hydrogen peroxide with side effects toward normal tissues. Herein, spherical mesoporous Fe-N-C single-atom nanozyme (SAzyme) is designed for antibacterial therapy via photothermal treatment enhanced Fenton-like catalysis process. Due to the large pore size (4.0 nm), high specific surface area (413.9 m2 g−1) and uniform diameter (100 nm), the catalytic performance of Fe-N-C SAzyme is greatly improved. The Michaelis-Menten constant (Km) is 4.84 mmol L−1, which is similar with that of horseradish peroxidase (3.7 mmol L−1). Moreover, mesoporous Fe-N-C SAzyme shows high photothermal conversion efficiency (23.3 %) owing to the carbon framework. The catalytic activity can be enhanced under light irradiation due to the elevated reaction temperature. The bacteria can also be killed via physical heat effect. Due to the synergistic effect of nanozyme catalysis and photothermal treatment, the antibacterial performance is much higher than that using single antibacterial method. This work provides an alternative for combined antibacterial treatment via photothermal treatment assisted catalytic process using spherical mesoporous single-atom nanozyme as an antibiotic.
- Subjects :
- chemistry.chemical_classification
Reactive oxygen species
biology
chemistry.chemical_element
Hydrogen Peroxide
Photothermal therapy
Combinatorial chemistry
Horseradish peroxidase
Carbon
Catalysis
Anti-Bacterial Agents
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Biomaterials
chemistry.chemical_compound
Colloid and Surface Chemistry
chemistry
Specific surface area
biology.protein
Reactive Oxygen Species
Hydrogen peroxide
Mesoporous material
Subjects
Details
- ISSN :
- 00219797
- Volume :
- 606
- Database :
- OpenAIRE
- Journal :
- Journal of Colloid and Interface Science
- Accession number :
- edsair.doi.dedup.....34b9022dcb9eb547df4d7da27721c7cf