Supplementary Tables S1-S8 and Figures S1-S3 from DNA Topoisomerase I Gene Copy Number and mRNA Expression Assessed as Predictive Biomarkers for Adjuvant Irinotecan in Stage II/III Colon Cancer

Supplementary Table S1: Baseline characteristics of biomarker stage III vs PETACC3 stage III. Supplementary Table S2: Baseline characteristics of biomarker stage II + III vs PETACC3 stage II + III. Supplementary Table S3: Treatment effects in the biomarker populations vs PETACC3. Supplementary Table S4: Associations between the TOP1 gene copy number and baseline characteristics, stage II + III. Supplementary Table S5: Associations between the TOP1 gene copy number and baseline characteristics, stage III. Supplementary Table S6: Associations between the TOP1/CEN20 ratio and baseline characteristics, stage II + III. Supplementary Table S7: Associations between the TOP1/CEN20 ratio and baseline characteristics, stage III. Supplementary Table S8: Associations between TOP1 mRNA expression and baseline characteristics, stage III. Supplementary Figure S1: CONSORT diagram Supplementary Figure S2: Inter-observer agreement of FISH counting, Bland-Altman plots. Supplementary Figure S3: Correlation between TOP1 FISH and TOP1 mRNA expression.