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Expression of the hippo signalling pathway effector YAP during canine epidermal tumourigenesis
- Source :
- Research in Veterinary Science. 130:93-97
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Cutaneous papilloma (CP) and cutaneous squamous cell carcinoma (CSCC) are frequent epidermal tumours in dogs. In this regard, the study of the deregulated activity of signalling molecules during the epidermal tumourigenesis process could be the basis for the development of novel molecular mechanism-based antitumour treatments for CP and CSCC canine patients. Recent evidence suggests that the development and progression of CP and CSCC involve the dysregulated activation of the Hippo signalling pathway effector YAP. Thus, in the present study, we evaluated the immunohistochemical expression pattern of YAP in sections of tissue microarrays constructed from canine samples of normal epidermis, CP, preneoplastic epidermis, and CSCC. In samples of CP, preneoplastic epidermis, and CSCC, YAP expression was significantly increased relative to normal epidermis. This emerging evidence suggests that the dysregulated activity of the Hippo signalling pathway effector YAP represents a frequent event during canine epidermal tumourigenesis, pointing to this protein as a potential therapeutic target for the treatment of CP and CSCC in dogs.
- Subjects :
- Skin Neoplasms
Carcinogenesis
040301 veterinary sciences
Cutaneous papilloma
Biology
0403 veterinary science
03 medical and health sciences
Dogs
Expression pattern
Animals
Dog Diseases
Adaptor Proteins, Signal Transducing
030304 developmental biology
0303 health sciences
Tissue microarray
Papilloma
General Veterinary
Epidermis (botany)
Effector
Gene Expression Profiling
04 agricultural and veterinary sciences
Hedgehog signaling pathway
Tissue Array Analysis
Carcinoma, Squamous Cell
Cancer research
Molecular mechanism
Immunohistochemistry
Epidermis
Signal Transduction
Subjects
Details
- ISSN :
- 00345288
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Research in Veterinary Science
- Accession number :
- edsair.doi.dedup.....34b66a52f03ff08ff6a56572e208e9ee