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In vivo therapeutic applications of phosphorus dendrimers: state of the art
- Source :
- Drug Discovery Today, Drug Discovery Today, 2021, 26 (3), pp.677-689. ⟨10.1016/j.drudis.2020.11.034⟩, Drug Discovery Today, Elsevier, 2021, 26 (3), pp.677-689. ⟨10.1016/j.drudis.2020.11.034⟩
- Publication Year :
- 2021
- Publisher :
- HAL CCSD, 2021.
-
Abstract
- International audience; Among the different types of dendrimers, those that incorporate phosphorus in various positions in their structures present fascinating properties and have wide applications in pharmaceutical fields such as drug delivery (including gene transfection), diagnosis and imaging. Therapeutic agents can be encapsulated within the dendritic architecture, or chemically attached or physically adsorbed onto the dendrimer surface. Alternatively, phosphorus dendrimers can be developed as drugs themselves, for instance to treat cancer, inflammations, infections and neurodegenerative diseases, although there are fewer examples of this second approach. Here, we review the most relevant in vivo biological activities of phosphorus dendrimers (whether as active drugs per se or as nanocarriers) across various therapeutic domains, including anti-inflammation, transmissible spongiform encephalopathies, ocular hypertension, infection, gene therapy, ultrasound-targeted microbubble destruction and two-photon in vivo imaging. We discuss the success of phosphorus dendrimers in nanomedicine and look ahead to future innovations in the field.
- Subjects :
- Diagnostic Imaging
0301 basic medicine
Dendrimers
chemistry.chemical_element
Nanotechnology
03 medical and health sciences
Drug Delivery Systems
0302 clinical medicine
In vivo
Dendrimer
Drug Discovery
Animals
Humans
[CHIM.COOR]Chemical Sciences/Coordination chemistry
Pharmacology
Drug Carriers
Phosphorus
3. Good health
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Drug delivery
Dendritic architecture
Nanoparticles
Nanomedicine
Nanocarriers
Preclinical imaging
Subjects
Details
- Language :
- English
- ISSN :
- 13596446
- Database :
- OpenAIRE
- Journal :
- Drug Discovery Today, Drug Discovery Today, 2021, 26 (3), pp.677-689. ⟨10.1016/j.drudis.2020.11.034⟩, Drug Discovery Today, Elsevier, 2021, 26 (3), pp.677-689. ⟨10.1016/j.drudis.2020.11.034⟩
- Accession number :
- edsair.doi.dedup.....34b448585ee7d8be4da3514afbf5eae1