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Epidural compression in neuroblastoma: Diagnostic and therapeutic aspects
- Source :
- Cancer Letters. 228:283-299
- Publication Year :
- 2005
- Publisher :
- Elsevier BV, 2005.
-
Abstract
- The involvement by tumour of intervertebral foramina and the consequent invasion of the spinal space, accompanied or not by neurological symptoms, represent a well-recognised pattern of presentation of neuroblastoma. The main peculiarity of this condition stands in the fact that, in case of its late detection or inadequate treatment, severe, permanent neurological compromise may ensue. Surprisingly enough, remarkable disagreements still exist regarding its optimal treatment and the related literature provide contrasting indications at this respect. The neurosurgical and the chemotherapeutic approaches have equally convinced supporters, while the use of radiation therapy is uncommon, possibly without good reasons. This mini-review intends to report the clinical experiences of the major Paediatric Oncology Groups with the aim to collect as many data as possible in the perspective of establishing common guidelines for proper diagnosing and treatment of this important complication.
- Subjects :
- Diagnostic Imaging
Male
Cancer Research
medicine.medical_specialty
Epidural compression
medicine.medical_treatment
Treatment outcome
Antineoplastic Agents
neuroblastoma
Neuroblastoma
Spinal cord compression
spinal cord compression
medicine
late effects
Humans
Intensive care medicine
Radiotherapy
business.industry
Paediatric oncology
Optimal treatment
Infant
medicine.disease
Surgery
Radiation therapy
epidural compression
Treatment Outcome
Oncology
Female
business
Spinal Cord Compression
Subjects
Details
- ISSN :
- 03043835
- Volume :
- 228
- Database :
- OpenAIRE
- Journal :
- Cancer Letters
- Accession number :
- edsair.doi.dedup.....34a7514acfc20842f254848139aa04f3