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Intestinal function and metabolism in the early adaptive phase after massive small bowel resection in the rat
- Source :
- Journal of Pediatric Surgery, 36(12), 1746-1751. W B Saunders Co-Elsevier Inc
- Publication Year :
- 2001
-
Abstract
- Intestinal function and metabolism in the early adaptive phase after massive small bowel resection in the rat.Welters CF, Dejong CH, Deutz NE, Heineman E.Department of Surgery, University Hospital Maastricht, Maastricht University, Maastricht, The Netherlands.PURPOSE: The aim of this study was to investigate the early adaptive responses in metabolism and gut function after massive small bowel resection. METHODS: Male Wistar rats underwent an 80% small bowel resection (Ent group, n = 9) or a transection and reanastomozing (Sham group, n = 7). After 24 hours, substrate fluxes across the gut were determined together with intestinal protein synthesis, polyamine concentrations in gut tissue, and gut function by testing intestinal permeability using the urinary recovery of lactulose and rhamnose. To test for the effect of starvation, healthy starved rats were studied. RESULTS: In the Ent group, intestinal uptake of glucose, lactate, glutamine, phenylalanine, branched chain amino acids, and total amino acids were equal to or higher than that in Sham rats. Intestinal protein synthesis increased, accompanied by an increase in spermidine to spermine polyamine ratios in the ileum and in the jejunal muscular layer. The urinary lactulose to rhamnose ratio also increased, suggesting increased intestinal permeability. CONCLUSIONS: 24 hours after massive small bowel resection, adaptive responses in metabolism and gut function already can be observed, as indicated by increased intestinal uptake of substrates and increased protein synthesis. This, however, is accompanied by an increase in intestinal permeability, which may indicate impaired intestinal barrier function. J Pediatr Surg 36:1746-1751. Copyright 2001 by W.B. Saunders Company.
- Subjects :
- Male
Short Bowel Syndrome
medicine.medical_specialty
Spermine
Ileum
Gastroenterology
Permeability
chemistry.chemical_compound
Lactulose
Internal medicine
Intestine, Small
medicine
Animals
Postoperative Period
Amino Acids
Intestinal Mucosa
Rats, Wistar
Digestive System Surgical Procedures
Intestinal permeability
business.industry
Anastomosis, Surgical
General Medicine
medicine.disease
Short bowel syndrome
Adaptation, Physiological
Small intestine
Rats
Intestines
Spermidine
Glutamine
Disease Models, Animal
medicine.anatomical_structure
Intestinal Absorption
chemistry
Protein Biosynthesis
Pediatrics, Perinatology and Child Health
Surgery
Gastrointestinal Motility
business
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 00223468
- Database :
- OpenAIRE
- Journal :
- Journal of Pediatric Surgery, 36(12), 1746-1751. W B Saunders Co-Elsevier Inc
- Accession number :
- edsair.doi.dedup.....349aa82718189d619fba2762272b8e81