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The recurrence and progression risk after simultaneous endoscopic surgery of urothelial bladder tumour and benign prostatic hyperplasia: a systematic review and meta‐analysis
- Source :
- Bju International
- Publication Year :
- 2020
- Publisher :
- John Wiley and Sons Inc., 2020.
-
Abstract
- Objectives To evaluate recurrence and progression risk after simultaneous endoscopic surgery of bladder cancer and benign prostatic hyperplasia (BPH), as simultaneous surgery is not an unusual scenario and theoretically simultaneous transurethral resection of bladder tumour (TURBT) and transurethral resection of the prostate (TURP) can lead to an increased risk of recurrence in the bladder neck and prostatic urethra (BN/PU). Methods We conducted a systematic review and meta-analysis to assess the risk of recurrence (i.e. whole bladder and/or BN/PU) and tumour progression as outcomes after a simultaneous endoscopic surgery of bladder tumour and BPH, as compared to TURBT alone. We queried PubMed and Web of Science database on 1 January 2020. We used random- and/or fixed-effects meta-analytic models in the presence or absence of heterogeneity according to the I2 statistic, respectively. Results Nine retrospective and three clinical trial studies were selected after considering inclusion and exclusion criteria. We conducted the meta-analysis on retrospective and randomised controlled trials (RCTs) separately. Eight retrospective and three RCT studies were included to assess the BN/PU recurrence risk and the summarised risk ratio (RR) was 1.02 (95% confidence interval [CI] 0.74-1.41) and 0.93 (95% CI 0.47-1.84), respectively. Five retrospective and two RCT studies were included to assess the progression risk and the summarised RR was 0.91 (95% CI 0.56-1.48) and 1.16 (95% CI 0.30-4.51), respectively. Eight retrospective and three RCT studies were included to assess the whole bladder recurrence risk and the summarised RR was 0.87 (95% CI 0.78-0.97) and 0.89 (95% CI 0.65-1.21), respectively. Conclusion We did not observe any increased risk of total bladder recurrence, BN/PU recurrence, or progression after a simultaneous endoscopic surgery of bladder tumour and BPH, as compared to TURBT alone.
- Subjects :
- Male
medicine.medical_specialty
Urology
medicine.medical_treatment
Urinary Bladder
030232 urology & nephrology
Prostatic Hyperplasia
Reviews
Review
urologic and male genital diseases
Cystectomy
law.invention
03 medical and health sciences
endoscopic surgery
#blcsm
0302 clinical medicine
Randomized controlled trial
Prostatic urethra
law
medicine
Humans
Transurethral resection of the prostate
benign prostatic hyperplasia
Bladder cancer
simultaneous surgery
business.industry
#BladderCancer
Transurethral Resection of Prostate
medicine.disease
TURBT
Clinical trial
Neck of urinary bladder
TURP
medicine.anatomical_structure
Urinary Bladder Neoplasms
030220 oncology & carcinogenesis
Relative risk
Inclusion and exclusion criteria
bladder cancer
Neoplasm Recurrence, Local
business
Subjects
Details
- Language :
- English
- ISSN :
- 1464410X and 14644096
- Volume :
- 127
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Bju International
- Accession number :
- edsair.doi.dedup.....3497a62d46aab7f1e718d369897f38a8