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Effects of antenatal betamethasone on preterm human and mouse ductus arteriosus: comparison with baboon data
- Source :
- Pediatric research, vol 84, iss 3, Pediatric research
- Publication Year :
- 2018
- Publisher :
- eScholarship, University of California, 2018.
-
Abstract
- Background Although studies involving preterm infants ≤34 weeks gestation report a decreased incidence of patent ductus arteriosus after antenatal betamethasone, studies involving younger gestation infants report conflicting results. Methods We used preterm baboons, mice and humans (≤276/7 weeks gestation) to examine betamethasone’s effects on ductus gene expression and constriction both in vitro and in vivo. Results In mice, betamethasone increased the sensitivity of the premature ductus to the contractile effects of oxygen without altering the effects of other contractile or vasodilatory stimuli. Betamethasone’s effects on oxygen sensitivity could be eliminated by inhibiting endogenous prostaglandin/nitric oxide signaling. In mice and baboons, betamethasone increased the expression of several developmentally-regulated genes that mediate oxygen-induced constriction (K+ channels) and inhibit vasodilator signaling (phosphodiesterases). In human infants, betamethasone increased the rate of ductus constriction at all gestational ages. However, in infants born ≤256/7 weeks gestation, betamethasone’s contractile effects were only apparent when prostaglandin signaling was inhibited, whereas, at 26-27 weeks gestation betamethasone’s contractile effects were apparent even in the absence of prostaglandin inhibitors. Conclusions We speculate that betamethasone’s contractile effects may be mediated through genes that are developmentally regulated. This could explain why betamethasone’s effects vary according to the infant’s developmental age at birth.
- Subjects :
- Vasodilation
Betamethasone
Polymerase Chain Reaction
Pediatrics
chemistry.chemical_compound
Mice
0302 clinical medicine
Ductus arteriosus
Ductus Arteriosus, Patent
030219 obstetrics & reproductive medicine
biology
medicine.anatomical_structure
Echocardiography
Maternal Exposure
cardiovascular system
Public Health and Health Services
Gestation
Patent
Female
Infant, Premature
medicine.drug
medicine.medical_specialty
Prostaglandin
Article
Paediatrics and Reproductive Medicine
03 medical and health sciences
In vivo
030225 pediatrics
biology.animal
Internal medicine
medicine
Animals
Humans
Premature
business.industry
Gene Expression Profiling
Infant
Ductus Arteriosus
Oxygen
Endocrinology
chemistry
Gene Expression Regulation
Pediatrics, Perinatology and Child Health
Prostaglandin inhibitor
Prostaglandins
business
Baboon
Papio
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Pediatric research, vol 84, iss 3, Pediatric research
- Accession number :
- edsair.doi.dedup.....34829259a5bffa024eb6dcb7fd389632