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Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
- Source :
- European Journal of Pediatrics
- Publication Year :
- 2020
- Publisher :
- Springer Berlin Heidelberg, 2020.
-
Abstract
- Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment.Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect. What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation. What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.
- Subjects :
- Male
medicine.medical_treatment
Short Communication
Less invasive
LISA – CPAP
law.invention
Catheterization
03 medical and health sciences
0302 clinical medicine
Pulmonary surfactant
Randomized controlled trial
law
030225 pediatrics
medicine
Humans
030212 general & internal medicine
Growth Disorders
Outcome
Mechanical ventilation
Respiratory Distress Syndrome, Newborn
Continuous Positive Airway Pressure
business.industry
Premature infants
Standard treatment
Infant, Newborn
Pulmonary Surfactants
Respiration, Artificial
Catheter
Treatment Outcome
Neurodevelopmental Disorders
Anesthesia
Child, Preschool
Pediatrics, Perinatology and Child Health
Breathing
Female
Less invasive surfactant
Outcome data
business
Infant, Premature
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 14321076 and 03406199
- Volume :
- 179
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- European Journal of Pediatrics
- Accession number :
- edsair.doi.dedup.....347fbbf39ffa9961932d481aa86f0661