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Research into the Physiology of Cerebrospinal Fluid Reaches a New Horizon: Intimate Exchange between Cerebrospinal Fluid and Interstitial Fluid May Contribute to Maintenance of Homeostasis in the Central Nervous System
- Source :
- Neurologia medico-chirurgica
- Publication Year :
- 2016
- Publisher :
- Japan Neurosurgical Society, 2016.
-
Abstract
- Cerebrospinal fluid (CSF) plays an essential role in maintaining the homeostasis of the central nervous system. The functions of CSF include: (1) buoyancy of the brain, spinal cord, and nerves; (2) volume adjustment in the cranial cavity; (3) nutrient transport; (4) protein or peptide transport; (5) brain volume regulation through osmoregulation; (6) buffering effect against external forces; (7) signal transduction; (8) drug transport; (9) immune system control; (10) elimination of metabolites and unnecessary substances; and finally (11) cooling of heat generated by neural activity. For CSF to fully mediate these functions, fluid-like movement in the ventricles and subarachnoid space is necessary. Furthermore, the relationship between the behaviors of CSF and interstitial fluid in the brain and spinal cord is important. In this review, we will present classical studies on CSF circulation from its discovery over 2,000 years ago, and will subsequently introduce functions that were recently discovered such as CSF production and absorption, water molecule movement in the interstitial space, exchange between interstitial fluid and CSF, and drainage of CSF and interstitial fluid into both the venous and the lymphatic systems. Finally, we will summarize future challenges in research. This review includes articles published up to February 2016.
- Subjects :
- Central Nervous System
0301 basic medicine
Pathology
medicine.medical_specialty
interstitial fluid
Central nervous system
Review Article
cerebrospinal fluid
03 medical and health sciences
0302 clinical medicine
Cerebrospinal fluid
Interstitial space
Interstitial fluid
medicine
Homeostasis
Humans
business.industry
Extracellular Fluid
lymphatic drainage
Spinal cord
Virchow-Robin space
aquaporin
030104 developmental biology
medicine.anatomical_structure
Peptide transport
Surgery
Glymphatic system
Neurology (clinical)
Erratum
Subarachnoid space
business
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13498029 and 04708105
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- Neurologia medico-chirurgica
- Accession number :
- edsair.doi.dedup.....347becd5d9940f9329a9d59583b5cb7a