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Lymphatic Changes in Respiratory Diseases: More than Just Remodeling of the Lung?
- Source :
- American journal of respiratory cell and molecular biology. 57(3)
- Publication Year :
- 2017
-
Abstract
- Advances in our ability to identify lymphatic endothelial cells and differentiate them from blood endothelial cells have led to important progress in the study of lymphatic biology. Over the past decade, preclinical and clinical studies have shown that there are changes to the lymphatic vasculature in nearly all lung diseases. Efforts to understand the contribution of lymphatics and their growth factors to disease initiation, progression, and resolution have led to seminal findings establishing critical roles for lymphatics in lung biology spanning from the first breath after birth to asthma, tuberculosis, and lung transplantation. However, in other diseases, it remains unclear if lymphatics are part of the overall lung remodeling process or real contributors to disease pathogenesis. The goal of this Translational Review is to highlight some of the advances in our understanding of the role(s) of lymphatics in lung disease and shed light on the critical needs and unanswered questions that might lead to novel translational applications.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Pathology
medicine.medical_specialty
Tuberculosis
medicine.medical_treatment
government.form_of_government
Clinical Biochemistry
Disease
Lymphatic System
03 medical and health sciences
Medicine
Lung transplantation
Animals
Humans
Respiratory system
Lymphangiogenesis
Molecular Biology
Lung
Lymphatic Vessels
business.industry
Cell Biology
medicine.disease
Respiration Disorders
Lymphatic Endothelium
030104 developmental biology
medicine.anatomical_structure
Lymphatic system
Translational Review
government
Airway Remodeling
business
Subjects
Details
- ISSN :
- 15354989
- Volume :
- 57
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- American journal of respiratory cell and molecular biology
- Accession number :
- edsair.doi.dedup.....347b0f6a2811fb1508fb1d27ba0fe948