Human T-cells recognise N-terminally Fmoc-modified peptide

Authors :: Stuart I. Mannering
Anthony W. Purcell
James McCluskey
Leonard C. Harrison
Margo C. Honeyman
Source :: Vaccine. 21(25-26)
Publication Year :: 2003
Abstract: We aimed to generate T-cell clones specific for human pre-proinsulin. An HLA DQ8, CD4+ T-cell clone that recognised a 10mer (C65-A9) peptide from pre-proinsulin was isolated. Further analysis revealed that the clone responded neither to recombinant proinsulin nor to re-synthesised C65-A9 peptide. Analysis of the original peptide revealed minor contamination (

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