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Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype

Authors :
Klaus Fliessbach
Oliver Brüstle
Catrin Cornelia Thiele
Monika Veltel
Michael Peitz
Alfredo Ramirez
Melanie Bloschies
Tamara Bechler
Source :
Stem Cell Research, Vol 29, Iss, Pp 250-253 (2018), Stem Cell Research, Stem cell research 29, 250-253 (2018). doi:10.1016/j.scr.2018.04.011
Publication Year :
2018
Publisher :
Zenodo, 2018.

Abstract

Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.

Details

Language :
English
Database :
OpenAIRE
Journal :
Stem Cell Research, Vol 29, Iss, Pp 250-253 (2018), Stem Cell Research, Stem cell research 29, 250-253 (2018). doi:10.1016/j.scr.2018.04.011
Accession number :
edsair.doi.dedup.....346c0978d49054a6e1b3a655e169bee2
Full Text :
https://doi.org/10.1016/j.scr.2018.04.011