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Blood-derived integration-free iPS cell line UKBi011-A from a diagnosed male Alzheimer's disease patient with APOE ɛ4/ɛ4 genotype
- Source :
- Stem Cell Research, Vol 29, Iss, Pp 250-253 (2018), Stem Cell Research, Stem cell research 29, 250-253 (2018). doi:10.1016/j.scr.2018.04.011
- Publication Year :
- 2018
- Publisher :
- Zenodo, 2018.
-
Abstract
- Alzheimer's disease (AD) is most the frequent neurodegenerative disease, and the APOE ε4 allele is the most prominent risk factor for late-onset AD. Here, we present an iPSC line generated from peripheral blood cells of a male AD patient employing Sendai virus vectors encoding the transcription factors OCT4, SOX2, KLF4 and c-MYC. The characterized iPSC line expresses typical human pluripotency markers and shows differentiation into all three germ layers, complete reprogramming vector clearance, a normal SNP genotype and maintenance of the APOE ε4/ε4 allele.
- Subjects :
- Male
0301 basic medicine
Apolipoprotein E4
metabolism [Blood Cells]
genetics [Alzheimer Disease]
pathology [Alzheimer Disease]
0302 clinical medicine
neurodegenerative disease
Genotype
iPS cell line
Cellular Reprogramming Techniques
Vector (molecular biology)
Induced pluripotent stem cell
lcsh:QH301-705.5
genetics [Apolipoprotein E4]
Aged, 80 and over
diagnosis [Alzheimer Disease]
General Medicine
genetics [Transcription Factors]
Alzheimer's disease
pathology [Induced Pluripotent Stem Cells]
3. Good health
metabolism [Induced Pluripotent Stem Cells]
pathology [Blood Cells]
KLF4
embryonic structures
Reprogramming
metabolism [Alzheimer Disease]
APOE
Induced Pluripotent Stem Cells
Biology
Polymorphism, Single Nucleotide
biosynthesis [Transcription Factors]
Kruppel-Like Factor 4
03 medical and health sciences
metabolism [Apolipoprotein E4]
SOX2
Alzheimer Disease
ddc:570
Humans
SNP
Allele
Blood Cells
Cell Biology
030104 developmental biology
lcsh:Biology (General)
genotyping
Immunology
030217 neurology & neurosurgery
Transcription Factors
Developmental Biology
dementia
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Stem Cell Research, Vol 29, Iss, Pp 250-253 (2018), Stem Cell Research, Stem cell research 29, 250-253 (2018). doi:10.1016/j.scr.2018.04.011
- Accession number :
- edsair.doi.dedup.....346c0978d49054a6e1b3a655e169bee2
- Full Text :
- https://doi.org/10.1016/j.scr.2018.04.011