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Comparative proteomic analysis of human serum before and after liver transplantation using quantitative proteomics
- Source :
- Oncotarget
- Publication Year :
- 2019
- Publisher :
- Impact Journals, LLC, 2019.
-
Abstract
- Liver cancer is the second leading cause of cancer mortality worldwide. Safer and more effective diagnostic methods for liver cancer are desirable, and biomarkers represent a potentially alternative method for diagnosis. The present study was designed to identify liver cancer biomarkers. We quantified the changes in serum protein levels between liver transplantation and healthy (control) females using isobaric tags for relative and absolute quantitation (iTRAQ) as well as proteomic analysis. A total of 1399 proteins were identified; of these, three proteins showed significantly different concentrations between the before transplantation group and the control group. These proteins may thus be relevant to liver cancer and constitute potential liver cancer biomarkers.
- Subjects :
- 0301 basic medicine
Diagnostic methods
medicine.medical_treatment
Quantitative proteomics
Serum protein
Liver transplantation
Bioinformatics
Proteomics
03 medical and health sciences
proteomics
0302 clinical medicine
medicine
protein markers
Alternative methods
liver transplantation
pathway
business.industry
medicine.disease
Transplantation
030104 developmental biology
iTRAQ
Oncology
030220 oncology & carcinogenesis
Liver cancer
business
Research Paper
Subjects
Details
- ISSN :
- 19492553
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Oncotarget
- Accession number :
- edsair.doi.dedup.....345c16d30b4cbcbca50e563d672049e3