Back to Search
Start Over
Long-term surgical outcomes in patients with hepatocellular carcinoma undergoing laparoscopic vs. open liver resection: A retrospective and propensity score-matched study
- Source :
- Asian Journal of Surgery, Vol 44, Iss 1, Pp 206-212 (2021)
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Background/objectives There is limited availability of well-designed comparative studies using propensity score matching with a sufficient sample size to compare laparoscopic liver resection (LLR) vs. open liver resection (OLR) for hepatocellular carcinoma (HCC). We aimed to compare the feasibility and safety of LLR and OLR in patients with HCC. Methods We enrolled 168 patients who underwent elective LLR (n = 58) or OLR (n = 110) for HCC in two tertiary medical centers between November 2009 and December 2018. Patients who underwent LLR were propensity score-matched to patients who underwent OLR in a 1:1 ratio. Perioperative and postoperative outcomes and disease-free and overall survival rates were prospectively evaluated. Results Among the 116 patients analyzed, 58 each belonged to the LLR and OLR groups. We performed 85 segmentectomies or sectionectomies, 19 left-lateral-sectionectomies, 9 left-hemihepatectomies, and 3 right-hemihepatectomies. There was no significant difference in age, sex, Child-Pugh class, original liver disease, preoperative alpha-fetoprotein, tumor size, tumor location, overall morbidity, and operative time. There was a significant difference in the length of postoperative hospital stay between the two groups (LLR vs OLR; 8 vs 10 days, p = 0.003). The 1-, 3-, and 5-year overall survival rates in the LLR and OLR groups were 96.6%, 92.8%, and 73.3% and 93.1%, 88.8%, and 76.1%, respectively (p = 0.642). The 1-, 3-, and 5-year disease-free survival rates in the LLR and OLR groups were 84.4%, 64.0%, and 60.2% and 93.1%, 67.4%, and 63.9%, respectively (p = 0.391). Conclusion LLR for HCC can be performed safely with acceptable short-term and long-term outcomes compared with OLR.
- Subjects :
- Adult
Male
medicine.medical_specialty
Carcinoma, Hepatocellular
Time Factors
Hepatocellular carcinoma
lcsh:Surgery
Disease-Free Survival
Young Adult
03 medical and health sciences
Liver disease
0302 clinical medicine
Laparoscopic
medicine
Hepatectomy
Humans
In patient
Prospective Studies
Propensity Score
Aged
Retrospective Studies
Aged, 80 and over
Open liver resection
Liver resection
business.industry
Liver Neoplasms
Perioperative
lcsh:RD1-811
Length of Stay
Middle Aged
medicine.disease
Surgery
Treatment Outcome
Liver
Sample size determination
030220 oncology & carcinogenesis
Propensity score matching
Feasibility Studies
Operative time
Female
Laparoscopy
030211 gastroenterology & hepatology
Safety
business
Subjects
Details
- Language :
- English
- ISSN :
- 10159584
- Volume :
- 44
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Surgery
- Accession number :
- edsair.doi.dedup.....345aad1b8a292d117441482b025b09d4