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Novel β-TCP/PVA bilayered hydrogels with considerable physical and bio-functional properties for osteochondral repair
- Publication Year :
- 2017
-
Abstract
- Cartilage repairing grafts have been widely studied, and osteochondral replacement hydrogels have proven to be an excellent method in research and clinical fields. However, it has been difficult to simultaneously solve three main issues in osteochondral replacement preparation: surface lubrication, overall mechanical support and good simulations of cell regeneration. A novel integrated bilayered hydrogel osteochondral replacement was constructed by blending polyvinyl alcohol (PVA) and β-tricalcium phosphate (β-TCP) in this study. Separated nano-ball milling with ultrasound dispersion prepared β-TCP demonstrated suitable properties of tiny particle size, high purity and ideal distribution, improving the mechanical properties of the novel integrated hydrogel, and providing a cartilage-like lubrication effect and high biocompatibility, including cytocompatibility and osteogenesis. The reinforcement of β-TCP and integrated molding technology enabled the hydrogel to demonstrate excellent component compatibility and good bonding between the two layers, which promoted the strengthening of the compression modulus and tensile modulus up to three times by mechanical testing. The surface lubrication properties of the novel osteochondral hydrogel were similar to the natural cartilage by friction coefficient characterization. The two layers of the novel integrated graft provided a considerable bio-function by co-culturing with chondrocytes and synovium mesenchymal stem cells: chondrocytes promoted adherence achieved by the upper density layer and better osteogenesis performance of the porous lower layer. The design of the bilayered β-TCP/PVA osteochondral hydrogel is promising for use in articular cartilage repair.
- Subjects :
- Calcium Phosphates
Cartilage, Articular
Materials science
Biocompatibility
Friction
Surface Properties
Swine
0206 medical engineering
Biomedical Engineering
Modulus
Bioengineering
Young's modulus
Biocompatible Materials
02 engineering and technology
Polyvinyl alcohol
Calcium Carbonate
Biomaterials
symbols.namesake
chemistry.chemical_compound
Chondrocytes
Osteogenesis
Materials Testing
medicine
Articular cartilage repair
Animals
β-TCP/PVA
Tissue Engineering
Tissue Scaffolds
Cartilage
Synovial Membrane
technology, industry, and agriculture
Chemical engineering [Engineering]
Mesenchymal Stem Cells
Hydrogels
021001 nanoscience & nanotechnology
020601 biomedical engineering
Coculture Techniques
medicine.anatomical_structure
chemistry
Polyvinyl Alcohol
Self-healing hydrogels
Lubrication
symbols
Stress, Mechanical
0210 nano-technology
Porosity
Biomedical engineering
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....34466f1e7bcb04be10f20a901257b386