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Transforming Growth Factor β1 Function in Airway Remodeling and Hyperresponsiveness. The Missing Link?
- Source :
- American Journal of Respiratory Cell and Molecular Biology. 56:432-442
- Publication Year :
- 2017
- Publisher :
- American Thoracic Society, 2017.
-
Abstract
- The pathogenesis of asthma includes a complex interplay among airway inflammation, hyperresponsiveness, and remodeling. Current evidence suggests that airway structural cells, including bronchial smooth muscle cells, myofibroblasts, fibroblasts, and epithelial cells, mediate all three aspects of asthma pathogenesis. Although studies show a connection between airway remodeling and changes in bronchomotor tone, the relationship between the two remains unclear. Transforming growth factor β1 (TGF-β1), a growth factor elevated in the airway of patients with asthma, plays a role in airway remodeling and in the shortening of various airway structural cells. However, the role of TGF-β1 in mediating airway hyperresponsiveness remains unclear. In this review, we summarize the literature addressing the role of TGF-β1 in airway remodeling and shortening. Through our review, we aim to further elucidate the role of TGF-β1 in asthma pathogenesis and the link between airway remodeling and airway hyperresponsiveness in asthma and to define TGF-β1 as a potential therapeutic target for reducing asthma morbidity and mortality.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
medicine.medical_treatment
Clinical Biochemistry
Models, Biological
Transforming Growth Factor beta1
Pathogenesis
03 medical and health sciences
Respiratory Hypersensitivity
medicine
Animals
Humans
Molecular Targeted Therapy
Lung
Molecular Biology
Asthma
business.industry
Growth factor
Cell Biology
respiratory system
medicine.disease
respiratory tract diseases
Translational Review
030104 developmental biology
Immunology
Airway Remodeling
Respiratory epithelium
Bronchoconstriction
medicine.symptom
business
Airway
Myofibroblast
Transforming growth factor
Subjects
Details
- ISSN :
- 15354989 and 10441549
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- American Journal of Respiratory Cell and Molecular Biology
- Accession number :
- edsair.doi.dedup.....342126f8eb3db003ca31986f9bc1436f