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Hypersensitivity pneumonitis related to imatinib mesylate therapy in a patient with chronic myeloid leukemia
- Source :
- Journal of Oncology Pharmacy Practice. 27:1762-1765
- Publication Year :
- 2020
- Publisher :
- SAGE Publications, 2020.
-
Abstract
- Introduction Pulmonary toxicity causally related to Imatinib (IM) therapy is uncommon in patients with chronic myeloid leukemia. Case report A 61-year-old patient with chronic myeloid leukemia was treated with IM at 400 mg daily dose. One month within IM, he developed skin lesions and then acute dyspnea and non-productive cough. Chest radiograph and high-resolution lung computed tomography (CT) revealed bilateral reticulonodular infiltration in both lungs. According to Naranjo's algorithm, the causality relationship with the drug is probable with a score of 7. The pharmacovigilance investigation was carried out and implicated IM Management & outcome: IM was discontinued and started steroid therapy (Prednisolone®) at 1 mg/kg daily. Two weeks after, the dyspnea, and abnormal X-ray and CT findings are improved. Discussion The early diagnosis of pulmonary toxicity related to IM therapy is needed to avoid further determinal effects of the drug.
- Subjects :
- Male
Oncology
medicine.medical_specialty
Myeloid
Pulmonary toxicity
Prednisolone
Antineoplastic Agents
03 medical and health sciences
0302 clinical medicine
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Internal medicine
medicine
Humans
Pharmacology (medical)
Lung
Pneumonitis
business.industry
Myeloid leukemia
Imatinib
Middle Aged
medicine.disease
medicine.anatomical_structure
Imatinib mesylate
030220 oncology & carcinogenesis
Toxicity
Imatinib Mesylate
030211 gastroenterology & hepatology
business
Hypersensitivity pneumonitis
Alveolitis, Extrinsic Allergic
medicine.drug
Subjects
Details
- ISSN :
- 1477092X and 10781552
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Journal of Oncology Pharmacy Practice
- Accession number :
- edsair.doi.dedup.....341064b300d7adf6744a775d94973506