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Functional mosaic organization of neuroligins in neuronal circuits
- Source :
- Cellular and Molecular Life Sciences. 77:3117-3127
- Publication Year :
- 2020
- Publisher :
- Springer Science and Business Media LLC, 2020.
-
Abstract
- Complex brain circuitry with feedforward and feedback systems regulates neuronal activity, enabling neural networks to process and drive the entire spectrum of cognitive, behavioral, sensory, and motor functions. Simultaneous orchestration of distinct cells and interconnected neural circuits is underpinned by hundreds of synaptic adhesion molecules that span synaptic junctions. Dysfunction of a single molecule or molecular interaction at synapses can lead to disrupted circuit activity and brain disorders. Neuroligins, a family of cell adhesion molecules, were first identified as postsynaptic-binding partners of presynaptic neurexins and are essential for synapse specification and maturation. Here, we review recent advances in our understanding of how this family of adhesion molecules controls neuronal circuit assembly by acting in a synapse-specific manner.
- Subjects :
- Neurons
Pharmacology
Cell adhesion molecule
Cell Adhesion Molecules, Neuronal
Brain
Sensory system
Cell Biology
Biology
Synaptic Transmission
Synapse
Cellular and Molecular Neuroscience
Neuronal circuits
Synapses
Biological neural network
Animals
Humans
Molecular Medicine
Premovement neuronal activity
Nerve Net
Molecular Biology
Neuroscience
Brain circuitry
Subjects
Details
- ISSN :
- 14209071 and 1420682X
- Volume :
- 77
- Database :
- OpenAIRE
- Journal :
- Cellular and Molecular Life Sciences
- Accession number :
- edsair.doi.dedup.....340a2f8ee56756456ac1f40bdad49258