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Association of Body Mass Index Changes during Neoadjuvant Chemotherapy with Pathologic Complete Response and Clinical Outcomes in Patients with Locally Advanced Breast Cancer
- Source :
- Journal of Cancer
- Publication Year :
- 2015
- Publisher :
- Ivyspring International Publisher, 2015.
-
Abstract
- The purpose of this study was to determine the association between body mass index (BMI) measurements (baseline BMI and changes in BMI during neoadjuvant systemic treatment [NST]) and clinical efficacy (pathologic complete response [pCR] rate and survival outcomes) in locally advanced breast cancer (LABC). We hypothesized that high baseline BMI and increases in BMI during NST are associated with lower pCR rates and poorer clinical outcomes in LABC. We retrospectively reviewed the medical records of 1002 patients, 204 with primary inflammatory breast cancer (IBC) and 798 with stage III non-IBC, who underwent standard NST and definitive surgery between November 1, 2006, and December 31, 2012. The median follow-up time for the survivors was 19.6 months (0.4 - 67.8 months). The pCR rates of patients whose BMI increased or decreased were 23.2% and 18.1%, respectively, (p=0.048). The unadjusted overall survival (OS) was significantly better in the group with increased BMI (p=0.006). However, increased BMI was not an independent predictor of pCR and clinical outcomes (recurrence-free survival and OS) after adjusting for other clinical variables. In subset analyses, increased BMI as a continuous variable was an independent predictor of higher pCR rates in the normal BMI/underweight group (odds ratio [OR]=1.35, 95% confidence interval [CI]: 1.06-0.71, p=0.015). Increased BMI (BMI change ≥0 vs.
- Subjects :
- Oncology
medicine.medical_specialty
Inflammatory breast cancer
Breast cancer
Body mass index change
Internal medicine
medicine
Stage (cooking)
Body mass index
Gynecology
Pathological complete response
business.industry
Medical record
nutritional and metabolic diseases
Odds ratio
medicine.disease
Confidence interval
Underweight
medicine.symptom
Predictive factor
business
Research Paper
Subjects
Details
- ISSN :
- 18379664
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer
- Accession number :
- edsair.doi.dedup.....33ff36ebe1415eb44af92e5ddcc5bd5d