Additional file 3 of CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in Huntington’s disease

Additional file 3. Genetic deletion of CK2α’ does not ameliorate anxiety-like behaviors or locomotor asymmetry of zQ175 HD at 12 months of age. a-e, Gross motor performance, exploratory behavior, and anxiety-like behavior were assessed during 30 mins in an open field test. a, distance traveled, b, time spent at the center of the field, c, average locomotion velocity and d, time in the outer/inner zone of the field between zQ175 and zQ175:CK2α’ (+/-). e, Representative tracing images show the total distance traveled by the subject. f, Parameters of the spontaneous motor activity (number of rears) evaluated by a cylinder test. Error bars denote mean ± SEM, values were analyzed by two-way ANOVA with Sidak’s post-hoc test. n.s = not significant.