Additional file 4 of CK2 alpha prime and alpha-synuclein pathogenic functional interaction mediates synaptic dysregulation in huntington’s disease

Additional file 4. CK2α’ does not alter cognitive behavior in symptomatic HD mice. a, b, Freezing time in the cued (a) and contextual fear conditioning test (b). c-e, Performance on the Barnes maze (BM) task measured by latency to reach the escape hole (c), the mean distance from the target location (d), and total distance until escape in training sessions (e). f-h, Results of BM reversal test are similar to those in BM test, measured by latency to first entry (f), total distance traveled (g) and the mean distance from the target location (h). i, working memory, percent of spontaneous alternation measured by Y maze. Tests were conducted in 12 month old zQ175 and zQ175:CK2α’(+/-).Error bars represent mean ± SEM. Statistical analyses were conducted using ANOVA with Sidak’s post-hoc test (n = 6 mice/genotype). n.s = not significant.