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Unraveling diagnostic uncertainty in transition phase from relapsing-remitting to secondary progressive multiple sclerosis
- Source :
- Multiple sclerosis and related disorders. 43
- Publication Year :
- 2020
-
Abstract
- Background: Clinicians struggle to timely diagnose secondary-progressive multiple sclerosis (SP-MS), with a ‘transition phase’ period of diagnostic uncertainty. We aimed at defining clinical markers predicting evolution to SP-MS. Methods:: We reviewed 210 newly diagnosed MS patients experiencing at least one confirmed disability worsening (CDW). CDWs were classified as disability worsening either due to incomplete recovery following relapse (r-CDW), or independent of relapse activity (nr-CDW). Logistic regression and Cox regression models were used to evaluate variables at CDW associated with SP-MS diagnosis. Results: On CDW, higher EDSS (OR: 2.73, p=0.002) and nr-CDW (OR: 2.63, p=0.03) were associated with conversion to SP-MS over the follow-up. In addition, the risk of SP-MS was higher in patients with EDSS>3.0 at CDW (HR: 2.26, p
- Subjects :
- medicine.medical_specialty
Multiple Sclerosis
predictor
Logistic regression
03 medical and health sciences
Disability Evaluation
0302 clinical medicine
Multiple Sclerosis, Relapsing-Remitting
Recurrence
Internal medicine
medicine
Humans
In patient
Disabled Persons
030212 general & internal medicine
First episode
business.industry
Proportional hazards model
Multiple sclerosis
Uncertainty
General Medicine
Multiple Sclerosis, Chronic Progressive
medicine.disease
Neurology
Relapsing remitting
disability
multiple sclerosi
Disease Progression
Secondary progressive multiple sclerosis
Biomarker (medicine)
biomarker
Neurology (clinical)
Progressive multiple sclerosis
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 22110356
- Volume :
- 43
- Database :
- OpenAIRE
- Journal :
- Multiple sclerosis and related disorders
- Accession number :
- edsair.doi.dedup.....33dae5a64a1df37619fe63db9a83d40d