Back to Search
Start Over
Recombinant human thrombopoietin prior to mobilization chemotherapy facilitates platelet recovery in autologous transplantation in patients with lymphoma: Results of a prospective randomized study
- Source :
- Chronic Diseases and Translational Medicine, Vol 7, Iss 3, Pp 190-198 (2021), Chronic Diseases and Translational Medicine
- Publication Year :
- 2021
- Publisher :
- KeAi Communications Co., Ltd., 2021.
-
Abstract
- Background: Chemotherapy plus granulocyte colony-stimulating factor (GCSF) regimen is one of the available approaches to mobilize peripheral blood progenitor cells (PBPCs). It causes thrombocytopenia and delays leukapheresis. This study aimed to evaluate the role of recombinant human thrombopoietin (rhTPO) before mobilization chemotherapy in facilitating leukapheresis in patients with lymphoma. Methods: In this randomized open-label phase 2 trial, patients were randomly assigned in a 1:2 ratio to receive mobilization with rhTPO plus GCSF in combination with chemotherapy (the rhTPO plus GCSF arm) or GCSF alone in combination with chemotherapy (the GCSF alone arm). The recovery of neutrophils and platelets and the amount of platelet transfusion were monitored. Results: Thirty patients were enrolled in this study between March 2016 and August 2018. Patients in the rhTPO plus GCSF arm (n = 10) had similar platelet nadir after mobilization chemotherapy (P=0.878) and similar amount of platelet transfusion (median 0 vs. 1 unit, P=0.735) when compared with the GCSF alone arm (n = 20). On the day of leukapheresis, the median platelet count was 86 × 109/L (range 18–219) among patients who received rhTPO and 73 × 109/L (range 42–197) among those who received GCSF alone (P=0.982). After the use of rhTPO, the incidence of platelet count
- Subjects :
- medicine.medical_specialty
Medicine (General)
Lymphoma
medicine.medical_treatment
Mobilization
030204 cardiovascular system & hematology
Gastroenterology
03 medical and health sciences
0302 clinical medicine
R5-920
Internal medicine
Medicine
Autologous transplantation
Platelet
Progenitor cell
Recombinant human thrombopoietin
Chemotherapy
business.industry
Recombinant Human Thrombopoietin
Leukapheresis
Regimen
Platelet transfusion
Schedule
030220 oncology & carcinogenesis
Original Article
business
Subjects
Details
- Language :
- English
- Volume :
- 7
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Chronic Diseases and Translational Medicine
- Accession number :
- edsair.doi.dedup.....33d97e2b2bcdfb00794646d002f38d3a