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ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
- Source :
- Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021), Communications Biology
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of this phenomena is warranted for vaccine development against SARS CoV-2. Here we report detailed immune profiling after ChAdOx1 nCoV-19 (AZD1222) and subsequent high dose challenge in two animal models of SARS-CoV-2 mediated disease. We demonstrate in rhesus macaques the lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced by prior vaccination with ChAdOx1 nCoV-19 which induced neutralising antibody responses after a single intramuscular administration. In a second animal model, ferrets, ChAdOx1 nCoV-19 reduced both virus shedding and lung pathology. Antibody titre were boosted by a second dose. Data from these challenge models on the absence of enhanced disease and the detailed immune profiling, support the continued clinical evaluation of ChAdOx1 nCoV-19.<br />Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in both models, including SARS-CoV-2 mediated pneumonia and virus shedding.
- Subjects :
- 0301 basic medicine
COVID-19 Vaccines
Live attenuated vaccines
QH301-705.5
viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Medicine (miscellaneous)
Disease
Article
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
ChAdOx1 nCoV-19
medicine
Animals
Biology (General)
Viral shedding
biology
SARS-CoV-2
business.industry
Ferrets
virus diseases
respiratory system
biochemical phenomena, metabolism, and nutrition
biology.organism_classification
medicine.disease
Antibodies, Neutralizing
Macaca mulatta
respiratory tract diseases
Vaccination
Rhesus macaque
Pneumonia
Titer
030104 developmental biology
Viral infection
Immunology
biology.protein
Antibody
General Agricultural and Biological Sciences
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 23993642
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Communications Biology
- Accession number :
- edsair.doi.dedup.....33d85c7556dab6aa65b5dd213486881c
- Full Text :
- https://doi.org/10.1038/s42003-021-02443-0