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ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models

Authors :
Nathan R Wiblin
Fergus V. Gleeson
Lauren Allen
Daniel B. Wright
Debbie J Harris
Leonie Alden
Teresa Lambe
Alexandra J. Spencer
Sarah C. Gilbert
Stephanie Leung
Miles W. Carroll
Kevin R. Bewley
Nadina Wand
Andrew White
Hannah Sharpe
Susan A. Fotheringham
Kathryn A. Ryan
Marta Ulaszewska
Gillian S. Slack
Carina Conceicao
Didier Ngabo
Stephen Thomas
Phillip Brown
Laura Hunter
Sue Charlton
Holly E. Humphries
Vanessa Lucas
Karen E. Gooch
Nazia Thakur
Ciaran Gilbride
Robert J. Watson
Catherine M K Ho
Emily Brunt
Rebecca Cobb
Sandra Belij-Rammerstorfer
Marilyn Aram
Breeze E. Cavell
Kelly M. Thomas
Dalan Bailey
Sally Sharpe
Laura Sibley
Charlotte Sarfas
Francisco J. Salguero
Chelsea L Kennard
Source :
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021), Communications Biology
Publication Year :
2021
Publisher :
Springer Science and Business Media LLC, 2021.

Abstract

Vaccines against SARS-CoV-2 are urgently required, but early development of vaccines against SARS-CoV-1 resulted in enhanced disease after vaccination. Careful assessment of this phenomena is warranted for vaccine development against SARS CoV-2. Here we report detailed immune profiling after ChAdOx1 nCoV-19 (AZD1222) and subsequent high dose challenge in two animal models of SARS-CoV-2 mediated disease. We demonstrate in rhesus macaques the lung pathology caused by SARS-CoV-2 mediated pneumonia is reduced by prior vaccination with ChAdOx1 nCoV-19 which induced neutralising antibody responses after a single intramuscular administration. In a second animal model, ferrets, ChAdOx1 nCoV-19 reduced both virus shedding and lung pathology. Antibody titre were boosted by a second dose. Data from these challenge models on the absence of enhanced disease and the detailed immune profiling, support the continued clinical evaluation of ChAdOx1 nCoV-19.<br />Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in both models, including SARS-CoV-2 mediated pneumonia and virus shedding.

Details

ISSN :
23993642
Volume :
4
Database :
OpenAIRE
Journal :
Communications Biology
Accession number :
edsair.doi.dedup.....33d85c7556dab6aa65b5dd213486881c
Full Text :
https://doi.org/10.1038/s42003-021-02443-0