Interpreting response to TMZ therapy in murine GL261 glioblastoma by combining Radiomics, Convex-NMF and feature selection in MRI/MRSI data analysis

Machine learning (ML) methods have shown great potential for the analysis of data involved in medical decisions. However, for these methods to be incorpored in the medical pipeline, they must be made interpretable not only to the data analyst, but also to the medical expert. In this work, we have applied a combination of feature transformation, selection and classification using ML and statistical methods to differentiate between control (untreated) and Temozolomide (TMZ)-treated tumour tissue from a glioblastoma (brain tumour) murine model. As input, we have used T2 weighted magnetic resonance images (MRI) and spectroscopic imaging (MRSI). Radiomics features have been extracted from the MRI dataset, while convex Non-negative Matrix Factorization (Convex-NMF) was used to extract sources from the MRSI dataset. Exhaustive feature selection has revealed parsimonious feature subsets that facilitate the expert interpretation of results while retaining a high discriminatory ability. L.M.N., A.V., C.A. and A.P.C. received EC funding from the ATTRACT project, under Grant Agreement 777222. A.V. and E.R. acknowledge funding from Spanish MINECO TIN2016- 79576-R research project.