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Relationship between serum and urine interleukin-6 elevations and renal scarring in children with acute pyelonephritis
- Source :
- Scandinavian journal of urology and nephrology. 43(2)
- Publication Year :
- 2008
-
Abstract
- Acute pyelonephritis is a common infectious disease in children and can result in permanent renal damage. Interleukin-6 (IL-6) is an important mediator of inflammation in response to bacterial infection. This study investigated the potential relationship between acute-phase IL-6 and subsequent renal scarring in children with a first time febrile acute pyelonephritis.In total, 79 children (age range 1-120 months) with a first time febrile urinary tract infection (UTI) were included. The diagnosis of acute pyelonephritis was confirmed by (99m)Tc-dimercaptosuccinic acid (DMSA) renal scan. Serum and urine samples were collected for IL-6 measurement by enzyme-linked immunosorbent assay before antibiotic treatment for the infection.The 79 children were divided into acute pyelonephritis (n=45) and lower UTI (n=34) groups according to the findings of DMSA scans. The initial serum and urine IL-6 levels of children with acute pyelonephritis were significantly higher compared with lower UTI (p0.001). Renal scarring was detected at the follow-up DMSA scans in 15 (34.1%) of the 44 children with acute pyelonephritis. Both serum and urine IL-6 levels during the acute phase of pyelonephritis were significantly higher in children with renal scarring than in those without (p=0.005 and p = 0.002). The median age of children with renal scarring was significantly lower than those without (p=0.034). Multiple regression analysis showed that higher initial serum and urine IL-6 levels and a younger age were associated with renal scarring.These results demonstrate that in younger children with a first time febrile acute pyelonephritis, elevations of the acute-phase serum and urine IL-6 levels were correlated with an increased risk of subsequent renal scarring.
- Subjects :
- Nephrology
Male
medicine.medical_specialty
medicine.drug_class
Urology
Urinary system
Antibiotics
Urine
Kidney
Gastroenterology
Internal medicine
medicine
Humans
Interleukin 6
Child
Chelating Agents
Vesico-Ureteral Reflux
biology
Pyelonephritis
business.industry
Interleukin-6
Infant, Newborn
Infant
medicine.disease
Surgery
medicine.anatomical_structure
El Niño
Child, Preschool
Acute Disease
biology.protein
Female
business
Succimer
Kidney disease
Subjects
Details
- ISSN :
- 00365599
- Volume :
- 43
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Scandinavian journal of urology and nephrology
- Accession number :
- edsair.doi.dedup.....33cde4f14c09922c7c3007772ff95a71