Molecular Cloning and Mapping of a Novel Human KRAB Domain-Containing C2H2-Type Zinc Finger to Chromosome 7q36.1

C2H2 zinc finger proteins constitute the largest family of transcription factors known with an estimated 300-500 genes encoding these proteins in the human genome. These proteins possess two conserved cysteines that are part of an antiparallel beta-sheet and two conserved histidines that are part of an alpha-helix, coordinated by a central zinc atom to form a globular domain. The protein family is typified by the RNA polymerase II transcription factor TFIIIA and the gap gene product Kruppel. 13 refs., 1 fig.