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Fat Metabolism Regulates Satiety Behavior in C. elegans
- Source :
- Scientific Reports
- Publication Year :
- 2016
- Publisher :
- Nature Publishing Group, 2016.
-
Abstract
- Animals change feeding behavior depending on their metabolic status; starved animals are eager to eat and satiated animals stop eating. C. elegans exhibits satiety quiescence under certain conditions that mimics many aspects of post-prandial sleep in mammals. Here we show that this feeding behavior depends on fat metabolism mediated by the SREBP-SCD pathway, an acetyl-CoA carboxylase (ACC) and certain nuclear hormone receptors (NRs). Mutations of the genes in the SREBP-SCD pathway reduce satiety quiescence. An RNA interference (RNAi) screen of the genes that regulate glucose and fatty acid metabolism identified an ACC necessary for satiety quiescence in C. elegans. ACC catalyzes the first step in de novo fatty acid biosynthesis known to be downstream of the SREBP pathway in mammals. We identified 28 NRs by microarray whose expression changes during refeeding after being starved. When individually knocked down by RNAi, 11 NRs among 28 affect both fat storage and satiety behavior. Our results show that the major fat metabolism pathway regulates feeding behavior and NRs could be the mediators to link the feeding behavior to the metabolic changes.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Gene Expression
Receptors, Cytoplasmic and Nuclear
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
RNA interference
Internal medicine
Gene expression
medicine
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Receptor
Multidisciplinary
biology
Fatty acid metabolism
Fatty Acids
Lipid metabolism
Feeding Behavior
Lipid Metabolism
biology.organism_classification
Sterol regulatory element-binding protein
030104 developmental biology
Endocrinology
Nuclear receptor
chemistry
Mutation
human activities
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....33a0bdc36d4e123b7ac17ef3933d2253
- Full Text :
- https://doi.org/10.1038/srep24841