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Clinicopathologic characteristics and therapeutic outcomes of primary gastrointestinal non-Hodgkin's lymphomas: 10 years of experience from a single center in eastern Anatolia
- Source :
- Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 18(5)
- Publication Year :
- 2008
-
Abstract
- Objective: The objective of this retrospective study was to report the clinicopathological data and the treatment outcomes in patients with primary gastrointestinal non-Hodgkin’s lymphoma. Patients and Methods: We carried out a retrospective analysis of 41 patients (22 females, 18 males, median age 58 and range 18–90 years) who presented to our department with histopathological diagnosis of primary gastrointestinal non-Hodgkin’s lymphoma between 1995 and 2004. Results: The stomach was the most common extranodal site and was seen in 25 of 41 (61%) patients. At presentation 28 (68.3%) patients had gastrointestinal symptoms while 27 (65.9%) had B symptoms. The range of follow-up was 2–84 months with a median of 9 months. The overall survival rate was 3 years for 25 (61.2%) patients. The 3-year overall survival rate was better in patients with early-stage disease (stages I and II1) who were treated with surgery plus chemotherapy and/or radiation therapy than in those treated with chemotherapy alone (91.6 vs. 50%, p < 0.05). The disease had a significant impact on both the progression-free survival and overall survival rates. Conclusion: Our data showed that surgical resection prior to postoperative chemotherapy was a better option for patients with early-stage disease with better patient survival.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Disease
Single Center
Gastroenterology
Young Adult
Internal medicine
medicine
Humans
Aged
Gastrointestinal Neoplasms
Neoplasm Staging
Retrospective Studies
Aged, 80 and over
Chemotherapy
business.industry
Stomach
Lymphoma, Non-Hodgkin
Retrospective cohort study
General Medicine
Middle Aged
medicine.disease
Prognosis
Survival Analysis
Surgery
Lymphoma
Radiation therapy
medicine.anatomical_structure
B symptoms
Chemotherapy, Adjuvant
Female
Radiotherapy, Adjuvant
medicine.symptom
business
Subjects
Details
- ISSN :
- 14230151
- Volume :
- 18
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Medical principles and practice : international journal of the Kuwait University, Health Science Centre
- Accession number :
- edsair.doi.dedup.....339a25f97a4bec50aba7e86fc622dabc