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Mast cells and lymphocyte subsets in pulps from healthy and carious human teeth
- Source :
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 103:e95-e102
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Objective To evaluate the presence of cytolytic T lymphocytes (CD8+), memory T cells (CD45RO+), helper T lymphocytes (CD4+), and mast cells in pulps from healthy and carious human teeth. Study design The teeth were separated into groups: I = unerupted; II = partially erupted, without caries; III = erupted, without caries; IV = erupted with shallow dentine caries; and V = teeth with pulp polyps. The immunoperoxidase staining procedure was used to detect CD8, CD45RO, CD4, and tryptase (mast cell marker) antigens. The number of each cell type was obtained by counting the number of cells per mm2. Results Mast cells were only present in pulp polyps. Pulps from carious teeth contained more CD4+ and CD8+cells than from noncarious teeth. There was a significant decrease in the number of lymphocytes in pulp polyps in comparison to the other groups. Conclusions Mast cells probably do not contribute to the early vascular or specific immune responses in the initial dental pulp pathosis, although they may be involved in a chronic phase of pulp inflammation such as pulp polyps. On the other hand, CD4+ and CD8+T cells participate mainly in initial phenomena of the immune response to incipient caries and seem not to substantially contribute to the response in pulp polyps.
- Subjects :
- Adult
CD4-Positive T-Lymphocytes
Adolescent
Helper T lymphocyte
CD8 Antigens
Tryptase
CD8-Positive T-Lymphocytes
Dental Caries
Immunoenzyme Techniques
Immune system
stomatognathic system
Antigen
T-Lymphocyte Subsets
Carious teeth
medicine
Humans
Lymphocyte Count
Mast Cells
General Dentistry
Dental Pulp
Analysis of Variance
biology
business.industry
Pulpitis
Mast cell
stomatognathic diseases
medicine.anatomical_structure
Otorhinolaryngology
CD4 Antigens
Immunology
biology.protein
Leukocyte Common Antigens
Pulp (tooth)
Tryptases
Surgery
Oral Surgery
business
Immunologic Memory
CD8
T-Lymphocytes, Cytotoxic
Subjects
Details
- ISSN :
- 10792104
- Volume :
- 103
- Database :
- OpenAIRE
- Journal :
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology
- Accession number :
- edsair.doi.dedup.....338b040de4cce24519bc42a10f27c907