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Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?
- Source :
- International Journal of Molecular Sciences, Vol 20, Iss 12, p 2906 (2019), International Journal of Molecular Sciences
- Publication Year :
- 2019
- Publisher :
- MDPI AG, 2019.
-
Abstract
- Over the last decades, a great array of molecular mediators have been identified as potential targets for the treatment of chronic pain. Among these mediators, transient receptor potential (TRP) channel superfamily members have been thoroughly studied. Namely, the nonselective cationic channel, transient receptor potential ankyrin subtype 1 (TRPA1), has been described as a chemical nocisensor involved in noxious cold and mechanical sensation and as rivalling TRPV1, which traditionally has been considered as the most important TRP channel involved in nociceptive transduction. However, few TRPA1-related drugs have succeeded in clinical trials. In the present review, we attempt to discuss the latest data on the topic and future directions for pharmacological intervention.
- Subjects :
- Nociception
Druggability
TRPV1
TRPV Cation Channels
Review
TRPA1
Catalysis
Nociceptive Pain
Inorganic Chemistry
lcsh:Chemistry
Transient receptor potential channel
medicine
Animals
Humans
pain
Physical and Theoretical Chemistry
TRPA1 Cation Channel
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Analgesics
business.industry
Organic Chemistry
Chronic pain
SUPERFAMILY
General Medicine
medicine.disease
Computer Science Applications
molecular modulation
lcsh:Biology (General)
lcsh:QD1-999
inflammation
Neuralgia
neuropathy
Chronic Pain
business
Neuroscience
psychological phenomena and processes
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Volume :
- 20
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....33899495c3910db9e3d46aa31dda6fa6