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Treatment of metastatic breast cancer by combination of chemotherapy and photothermal ablation using doxorubicin-loaded DNA wrapped gold nanorods
- Source :
- Biomaterials. 35(29)
- Publication Year :
- 2014
-
Abstract
- Despite the exciting advances in cancer therapy over past decades, tumor metastasis remains the dominate reason for cancer-related mortality. In present work, DNA-wrapped gold nanorods with doxorubicin (DOX)-loading (GNR@DOX) were developed for treatment of metastatic breast cancer via a combination of chemotherapy and photothermal ablation. The GNR@DOX nanoparticles induced significant temperature elevation and DOX release upon irradiation with near infrared (NIR) light as shown in the test tube studies. It was found that GNR@DOX nanoparticles in combination with laser irradiation caused higher cytotoxicity than free DOX in 4T1 breast cancer cells. Animal experiment with an orthotropic 4T1 mammary tumor model demonstrated that GNR@DOX nanoplatform significantly reduced the growth of primary tumors and suppressed their lung metastasis. The Hematoxylin and Eosin (H&E) and immunohistochemistry (IHC) staining assays confirmed that the tumor growth inhibition and metastasis prevention of GNR@DOX nanoparticles were attributed to their abilities to induce cellular apoptosis/necrosis and ablate intratumoral blood vessels. All these results suggested a considerable potential of GNR@DOX nanoplatform for treatment of metastatic breast cancer.
- Subjects :
- Pathology
medicine.medical_specialty
Materials science
Lung Neoplasms
medicine.medical_treatment
Biophysics
H&E stain
Mice, Nude
Bioengineering
Breast Neoplasms
macromolecular substances
Metastasis
Biomaterials
DNA Adducts
Cell Line, Tumor
polycyclic compounds
medicine
Animals
Humans
Doxorubicin
Breast
Cytotoxicity
Lung
Chemotherapy
Mammary tumor
Mice, Inbred BALB C
Antibiotics, Antineoplastic
Nanotubes
technology, industry, and agriculture
Hyperthermia, Induced
Phototherapy
medicine.disease
Metastatic breast cancer
carbohydrates (lipids)
Mechanics of Materials
Ceramics and Composites
Immunohistochemistry
Female
Gold
medicine.drug
Subjects
Details
- ISSN :
- 18785905
- Volume :
- 35
- Issue :
- 29
- Database :
- OpenAIRE
- Journal :
- Biomaterials
- Accession number :
- edsair.doi.dedup.....3386c451f28a9007351826fededbc305