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Thirty allele-level haplotypes centered around KIR2DL5 define the diversity in an African American population
- Source :
- Immunogenetics. 62:491-498
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- KIR2DL5 alleles were physically linked to alleles at adjacent KIR loci to define this region of KIR haplotypes in 55 gene-positive random African Americans. The majority carried KIR2DL5B. Three KIR2DL5A and six KIR2DL5B alleles that have been previously described and 11 novel KIR2DL5 alleles were identified by DNA sequencing. Novel alleles included variation that may impact promoter activity; two alleles carried nonsynonymous coding region variation. Based on linkage with KIR2DS1, KIR2DS3, KIR2DS5, KIR2DL2, KIR2DL3, and KIR3DS1 alleles, seven haplotypes of KIR2DL5A and 23 haplotypes of KIR2DL5B were observed. The phylogenetic relationships among the KIR2DL5 alleles predicted their association with either KIR2DS3 (six alleles) or KIR2DS5 (seven alleles). All of the KIR2DL5A alleles were linked either to KIR3DS1*01301 or KIR3DS1*049N. The majority of the KIR2DL5B alleles were linked to seven KIR2DL2 alleles; two were linked to a novel allele of KIR2DL3. These findings underscore the diversity of KIR haplotypes present in this population.
- Subjects :
- Nonsynonymous substitution
Linkage disequilibrium
Genetic Linkage
Immunology
Population
Killer-cell immunoglobulin-like receptor
Biology
Article
Receptors, KIR
Genetic linkage
Sequence Homology, Nucleic Acid
Genetic variation
Genetics
Humans
Allele
education
Alleles
Phylogeny
DNA Primers
education.field_of_study
Base Sequence
Haplotype
Genetic Variation
Black or African American
Receptors, KIR2DL5
Haplotypes
Receptors, KIR2DL3
Receptors, KIR2DL2
Subjects
Details
- ISSN :
- 14321211 and 00937711
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Immunogenetics
- Accession number :
- edsair.doi.dedup.....3384a01ee45063382171b09b4f3bf384