Back to Search
Start Over
Trends of beta-lactam antibiotic susceptibility in blood-borne methicillin-resistant Staphylococcus aureus (MRSA) and their linkage to the staphylococcal cassette chromosome mec (SCCmec) type
- Source :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 13(4)
- Publication Year :
- 2006
-
Abstract
- We investigated trends of beta-lactam antibiotic susceptibility in a total of 218 strains of blood-borne methicillin-resistant Staphylococcus aureus (MRSA) isolated from 1978 through 2002 at a middle-size geriatric hospital in Tokyo; the strains were classified by the MRSA marker, staphylococcal cassette chromosome mec (SCCmec). The minimum growth inhibitory concentration (MIC) of cloxacillin at which 50% of the strains were inhibited (MIC50) was 2 microg/ml in the strains isolated in 1978-1984 and 32 to 64 microg/ml in the strains isolated subsequently. Similarly, the MIC50 values of cefazolin and imipenem in the 1978-1984 isolates were 16 andor=0.25 microg/ml, respectively, and those in the strains isolated subsequently were 128 and 16 to 32 microg/ml, respectively. These results indicated that the MRSA strains isolated after 1985 had gained high-level resistance to beta-lactam antibiotics. The type of SCCmec was investigated by polymerase chain reaction (PCR). We observed an elevated frequency of type II SCCmec, from about 15% in the strains isolated in 1978-1984 to about 50% in the 1985-1989 isolates, and the frequency reached and remained at about 90% subsequently. These results imply that the high-level beta-lactam antibiotic resistance of the MRSA strains isolated after 1985 is most likely due to the increased integration of type II SCCmec.
- Subjects :
- Microbiology (medical)
Imipenem
Staphylococcus aureus
medicine.drug_class
Antibiotics
Cefazolin
Bacteremia
Biology
medicine.disease_cause
Microbiology
Cloxacillin
Antibiotic resistance
Japan
Drug Resistance, Multiple, Bacterial
medicine
Humans
Pharmacology (medical)
Retrospective Studies
SCCmec
biochemical phenomena, metabolism, and nutrition
Chromosomes, Bacterial
Staphylococcal Infections
bacterial infections and mycoses
Methicillin-resistant Staphylococcus aureus
Infectious Diseases
Methicillin Resistance
medicine.drug
Subjects
Details
- ISSN :
- 1341321X
- Volume :
- 13
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
- Accession number :
- edsair.doi.dedup.....33824f7dd4e6b1d81a6a58bfa3be81c7