Back to Search
Start Over
Cathepsin K inhibitor causes changes in crystallinity and crystal structure of newly-formed mandibular bone in rats
- Source :
- British Journal of Oral and Maxillofacial Surgery. 56:732-738
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Cathepsin K inhibitors are new drugs with the potential for the treatment of osteoporosis because they sustain bony remodelling better than bone resorption inhibitors such as bisphosphonates. The treatment of osteoporosis with inhibitors of bony resorption is associated with osteonecrosis of the jaw, as the deterioration in bony quality that they induce is thought to be one of its causes. The quality of bone is delineated by structural and material characteristics (which include the degree and quality of mineralisation, and depends on the content of proteoglycan and the structural integrity of the bony collagen).1,2 Animal and clinical studies have shown that cathepsin K inhibitors improve the mineral density and structural characteristics of bone, but their effect on the rest remains unknown. We therefore hypothesised that these inhibitors will affect the material characteristics of newly-formed mandibular bone. To verify our hypothesis, we used Raman microspectroscopy to examine such bone in rats that were given a cathepsin K inhibitor, and found unusual crystallinity and an increased substitution of carbonate (CO32-) in its crystal structure.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Cathepsin K
Osteoporosis
030209 endocrinology & metabolism
Mandible
03 medical and health sciences
Crystallinity
0302 clinical medicine
Bone Density
Internal medicine
medicine
Animals
Rats, Wistar
biology
business.industry
Biphenyl Compounds
medicine.disease
Rats
Raman microspectroscopy
Resorption
030104 developmental biology
Mineral density
Endocrinology
Otorhinolaryngology
Proteoglycan
biology.protein
Female
Surgery
Oral Surgery
Tomography, X-Ray Computed
Osteonecrosis of the jaw
business
Subjects
Details
- ISSN :
- 02664356
- Volume :
- 56
- Database :
- OpenAIRE
- Journal :
- British Journal of Oral and Maxillofacial Surgery
- Accession number :
- edsair.doi.dedup.....337f79496a4469afa11ff8c21b1764b7