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Neural mapping of anhedonia across psychiatric diagnoses: A transdiagnostic neuroimaging analysis
- Source :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 32, Iss, Pp 102825-(2021)
- Publication Year :
- 2021
-
Abstract
- Highlights • Anhedonia is present in many different psychiatric disorders. • Anhedonia has been associated with abnormal reward-related striatal dopamine functioning. • This study tested whether transdiagnostic anhedonia expression mapped onto striatal volume. • Our findings suggest volumetric abnormalities in the putamen and cerebellum as a common neural substrate of anhedonia severity that cut across psychiatric entities.<br />Anhedonia has been associated with abnormal reward-related striatal dopamine functioning in patients with different psychiatric disorders. Here, we tested whether anhedonia expression mapped onto striatal volume across several psychiatric diagnoses. T1-weighted images from 313 participants including 89 healthy controls (HC), 22 patients with opioid use disorder (OUD), 50 patients with major depressive disorder (MDD), 45 patients with borderline personality disorder (BPD), 49 patients with first-episode psychosis (FEP), 43 patients with cocaine use disorder (CUD) and 15 patients with schizophrenia (SZ) were included. Anhedonia was assessed with subscores of the Beck Depression Inventory (BDI) and/or the Scale for the Assessment of Negative Symptoms (SANS). Voxel-based morphometry (VBM) was conducted for identifying dimensional symptom-structure associations using region of interest (ROI, dorsal and ventral striatum) and whole-brain analyses, as well as for group comparisons of striatal volume. ROI analyses revealed significant negative relationships between putamen volume and BDI and SANS anhedonia scores across OUD, MDD, BPD, CUD and SZ patients (n = 175) and MDD, FEP and SZ patients (n = 114), respectively. Whole-brain VBM analyses confirmed these associations and further showed negative relationships between anhedonia severity and volume of the bilateral cerebellum. There were group differences in right accumbens volume, which however were not related to anhedonia expression across the different diagnoses. Our findings indicate volumetric abnormalities in the putamen and cerebellum as a common neural substrate of anhedonia severity that cut across psychiatric entities.
- Subjects :
- 2805 Cognitive Neuroscience
Psychosis
Anhedonia
Cognitive Neuroscience
Computer applications to medicine. Medical informatics
R858-859.7
Neuroimaging
610 Medicine & health
behavioral disciplines and activities
Neural correlate
Cerebellum
mental disorders
medicine
Humans
2741 Radiology, Nuclear Medicine and Imaging
Radiology, Nuclear Medicine and imaging
RC346-429
Scale for the Assessment of Negative Symptoms
Borderline personality disorder
Transdiagnostic
Depressive Disorder, Major
business.industry
Putamen
Beck Depression Inventory
Regular Article
medicine.disease
Magnetic Resonance Imaging
2728 Neurology (clinical)
Neurology
nervous system
Schizophrenia
10054 Clinic for Psychiatry, Psychotherapy, and Psychosomatics
2808 Neurology
Ventral Striatum
behavior and behavior mechanisms
Major depressive disorder
Neurology. Diseases of the nervous system
Neurology (clinical)
medicine.symptom
business
psychological phenomena and processes
Clinical psychology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- NeuroImage : Clinical, NeuroImage: Clinical, Vol 32, Iss, Pp 102825-(2021)
- Accession number :
- edsair.doi.dedup.....337d71f4d7f1de41f28daad2c97f5d19