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Optical Coherence Tomography (Angiography) Biomarkers in the Assessment and Monitoring of Diabetic Macular Edema
- Source :
- Journal of Diabetes Research, Vol 2020 (2020), Journal of Diabetes Research
- Publication Year :
- 2020
- Publisher :
- Hindawi Limited, 2020.
-
Abstract
- Retinopathy is one of the most severe diabetes-related complications, and macular edema is the major cause of central vision loss in patients with diabetes mellitus. Significant progress has been made in recent years in optical coherence tomography and angiography technology. At the same time, various parameters have been attributed the role of biomarkers creating the frame for new monitoring and treatment strategies and offering new insights into the pathogenesis of diabetic retinopathy and diabetic macular edema. In this review, we gathered the results of studies that investigated various specific OCT (angiography) parameters in diabetic macular edema, such as central subfoveal thickness (CST), cube average thickness (CAT), cube volume (CV), choroidal thickness (CT), retinal nerve fiber layer (RNFL), retinal thickness at the fovea (RTF), subfoveal choroidal thickness (SFCT), central macular thickness (CMT), choroidal vascularity index (CVI), total macular volume (TMV), central choroid thickness (CCT), photoreceptor outer segment (PROS), perfused capillary density (PCD), foveal avascular zone (FAZ), subfoveal neuroretinal detachment (SND), hyperreflective foci (HF), disorganization of the inner retinal layers (DRIL), ellipsoid zone (EZ), inner segment/outer segment (IS/OS) junctions, vascular density (VD), deep capillary plexus (DCP), and superficial capillary plexus (SCP), in order to provide a synthesis of biomarkers that are currently used for the early diagnosis, assessment, monitoring, and outlining of prognosis.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
genetic structures
Endocrinology, Diabetes and Metabolism
Nerve fiber layer
Review Article
Macular Edema
Diseases of the endocrine glands. Clinical endocrinology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Optical coherence tomography
Ophthalmology
Humans
Medicine
Macula Lutea
Fluorescein Angiography
Macular edema
Diabetic Retinopathy
medicine.diagnostic_test
business.industry
Retinal
Diabetic retinopathy
RC648-665
medicine.disease
Photoreceptor outer segment
eye diseases
030104 developmental biology
medicine.anatomical_structure
chemistry
030221 ophthalmology & optometry
sense organs
Choroid
business
Biomarkers
Tomography, Optical Coherence
Retinopathy
Subjects
Details
- ISSN :
- 23146753 and 23146745
- Volume :
- 2020
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Research
- Accession number :
- edsair.doi.dedup.....337842aa3d49e8ee99195caec580d80c