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Use of healthcare resources and drug expenditure before and after treatment of chronic hepatitis C with direct antiviral agents
- Source :
- Journal of viral hepatitisREFERENCES. 28(5)
- Publication Year :
- 2020
-
Abstract
- The aim of this study was to analyse the impact of treating chronic hepatitis C (CHC) with direct-acting agents (DAA) on the use of healthcare resources. We included all patients treated with DAA for CHC from January 2015 to December 2017 in Catalonia whose medical records from 12 months before to 24 months after treatment were available. Data were obtained from the Catalan Health Surveillance System. A total of 12,199 patients in Catalonia were treated with DAA for CHC. Of these, 11.3% had no-minimal fibrosis (F0-F1), 24.0% had moderate fibrosis (F2), 50.3% had significant fibrosis or cirrhosis (F3-F4), and 14.4% had decompensated cirrhosis. Use of healthcare resources decreased from the pre-treatment period to the post-treatment period for the following: hospital admissions due to complications of cirrhosis, from 0.19 to 0.12 per month per 100 patients (RR 0.57; 95% CI 0.47-0.68); length of hospital stay, from 12.9 to 12.2 days (RR 0.93; 95% CI 0.91-0.94); outpatient visits, from 65.0 to 49.2 (RR 0.75; 95% CI 0.74-0.75); and number of medication containers per patient per month, from 13.9 to 12.5 (RR 0.837; 95% CI 0.835-0.838). However, the number of invoices for antineoplastic treatment increased after DAA treatment, especially for patients with high morbidity or advanced fibrosis stage. In conclusion, a decrease in health resource use was seen in CHC patients treated with DAA, as measured by length of hospital stay, number of admissions due to cirrhosis complications, outpatient visits and overall drug invoicing. However, use of antineoplastic drugs increased significantly, especially in patients with cirrhosis and high morbidity.
- Subjects :
- Drug
Liver Cirrhosis
medicine.medical_specialty
Cirrhosis
media_common.quotation_subject
Antiviral Agents
03 medical and health sciences
0302 clinical medicine
Chronic hepatitis
Fibrosis
Virology
Internal medicine
Health care
medicine
Humans
030212 general & internal medicine
Stage (cooking)
media_common
Hepatology
business.industry
Medical record
Hepatitis C, Chronic
medicine.disease
Infectious Diseases
Pharmaceutical Preparations
030211 gastroenterology & hepatology
Health Expenditures
business
After treatment
Subjects
Details
- ISSN :
- 13652893
- Volume :
- 28
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of viral hepatitisREFERENCES
- Accession number :
- edsair.doi.dedup.....337259fd2eee7c6412ad7c4d2de4325a