Independent and combined associations of physical fitness components with inflammatory biomarkers in children and adolescents

[Background]: We aimed to examine the independent and combined associations of cardiorespiratory fitness, muscular fitness, and motor ability with single and clustered inflammatory biomarkers in children and adolescents.
[Methods]: This study included 503 children and adolescents. Cardiorespiratory fitness, upper- and lower-muscular fitness, and motor ability were assessed using field-based tests. Fasting blood samples were obtained to determine the levels of a set of inflammatory biomarkers. Global physical fitness and clustered inflammatory biomarker scores were computed. Associations between physical fitness and inflammatory biomarkers were analyzed through linear regression. Differences in inflammatory biomarker levels between physical fitness tertiles were tested.
[Results]: Global physical fitness was inversely associated with single and clustered inflammatory biomarkers in children (p
[Conclusion]: Physical fitness was negatively associated with single and clustered inflammatory biomarkers, independently of body mass index. Increasing physical fitness levels in youth might contribute to reduce the cardiovascular risk.
This work was supported by the National Plan for Research, Development, and Innovation (R + D + i) from the Spanish Ministry of Science and Innovation [DEP 2010-21662-C04-00 (DEP 2010-21662-C04-01: DEP 2010-21662-C04-02: DEP 2010-21662-C04-03: DEP 2010-21662-C04-04)]; and by the Spanish Ministry of Education [FPU15/05337].