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Whole-body hyperthermia combined with chemotherapy and intensity-modulated radiotherapy for treatment of advanced nasopharyngeal carcinoma: a retrospective study with propensity score matching

Authors :
Naiying Zheng
Zhihua Cai
Zhi-Wen Mo
Xiaoxue Xie
Ying Liang
Shao Xunfan
Anan Xu
Zhong Huang
Xiantao Lin
Jianming Tan
Source :
International Journal of Hyperthermia, Vol 38, Iss 1, Pp 1304-1312 (2021)
Publication Year :
2021

Abstract

Background Several studies have reported the combination of intracavity or cervical lymph node hyperthermia with chemoradiotherapy (CRT) to improve clinical outcomes in nasopharyngeal carcinoma (NPC), but the combination with whole-body hyperthermia (WBH) for treating NPC is unexplored. We aimed to assess the efficacy of the combination of radiotherapy, chemotherapy and WBH in patients with locoregionally advanced NPC. Methods Between July 2008 and November 2012, 239 newly diagnosed NPC patients were enrolled in a pre-propensity score-matched cohort, including 193 patients who received CRT (CRT group) and 46 who underwent CRT with WBH (HCRT group). The feasibility and clinical outcomes of both groups were evaluated and toxicities assessed. Survival rates were assessed using the Kaplan–Meier method, log-rank test and Cox regression. Results Following propensity score matching, 46 patients from each group were included. The 5-year overall survival (OS) rates were 65.2% in the CRT group and 80.3% in the HCRT group (p=.027). In contrast, the other survival outcomes at 5 years were similar between the groups: locoregional recurrence-free survival (LRRFS), 74.7% vs. 87.6% (p=.152); distant metastasis-free survival (DMFS), 67.4% vs. 77.9% (p=.125); and progression-free survival (PFS), 53.1% vs. 69.2% (p=.115). In the multivariate analyses, the only two independent predictors of OS were clinical stage and HCRT. Conclusions These results suggest that WBH, when combined with CRT, can improve the OS of patients with advanced NPC.

Details

ISSN :
14645157
Volume :
38
Issue :
1
Database :
OpenAIRE
Journal :
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
Accession number :
edsair.doi.dedup.....33552b90f224382ba5aa642085ed1f93