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Real-life experience with oral oxybutynin long-term continuous therapy in severe hyperhidrosis and systematic review of the literature
- Publication Year :
- 2021
-
Abstract
- Background Hyperhidrosis is a disorder of excessive sweating severely impacting on patient's quality of life (Qol). Several studies have been published about oral oxybutynin, but no studies focused on the achievement of complete clinical and Qol response. Objectives the aim of this study was to report our real-life experience with oral oxybutynin in patients with severe hyperhidrosis significantly affecting their Qol. Methods In this cohort retrospective study we enrolled, in a 3-year period, patients affected by severe hyperhidrosis with poor Qol, continuously treated with oral oxybutynin. Our outcome was the obtainment of complete clinical and Qol improvement. A systematic review of the literature was also performed reporting efficacy and safety of oral oxybutynin for primary hyperhidrosis. Results We enrolled 62 patients, of which 53 (85.5%) received a mean daily dose of 10 mg and 9 (15.5%) of 5 mg. Complete clinical response was achieved in 77.4% (48/62) of cases, while complete Qol improvement occurred in 51.6% (32/62) of cases. Adverse events were only reported as mild, with dry mouth being the most frequently observed (16.1%). Kaplan-Meier survival analysis highlighted that both median clinical and Qol complete responses were reached after 1 year of continuous therapy with oral oxybutynin. The main limitation of our study is the small number of patients enrolled. Conclusions Long-term therapy with oral oxybutynin for severe hyperhidrosis, continuously administered at a mean daily dosage of 5 to 10 mg, allowed the majority of our patients to reach both clinical and Qol complete improvement, without significant adverse events. This article is protected by copyright. All rights reserved.
- Subjects :
- Pediatrics
medicine.medical_specialty
Dermatology
Muscarinic Antagonists
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Quality of life
medicine
hyperhidrosis
oxybutynin
pharmacology
quality of life
Humans
Hyperhidrosis
hyperhidrosi
Oxybutynin
Adverse effect
Survival analysis
Retrospective Studies
business.industry
Retrospective cohort study
General Medicine
Dry mouth
humanities
Treatment Outcome
030220 oncology & carcinogenesis
Cohort
Quality of Life
Mandelic Acids
medicine.symptom
business
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....3354e73433d29c1e4153c0de7d2f2be4