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Functional effect of Saffron supplementation and risk genotypes in early age-related macular degeneration: a preliminary report
- Source :
- Journal of Translational Medicine
- Publication Year :
- 2013
-
Abstract
- Background To determine whether the functional effects of oral supplementation with Saffron, a natural compound that proved to be neuroprotective in early age-related macular degeneration, are influenced by complement factor H (CFH) and age-related maculopathy susceptibility 2 (ARMS2) risk genotypes. Methods Thirty-three early AMD patients, screened for CFH (rs1061170) and ARMS2 (rs10490924) polymorphisms and receiving Saffron oral supplementation (20 mg/day) over an average period of treatment of 11 months (range, 6–12), were longitudinally evaluated by clinical examination and focal electroretinogram (fERG)-derived macular (18°) flicker sensitivity estimate. fERG amplitude and macular sensitivity, the reciprocal value of the estimated fERG amplitude threshold, were the main outcome measures. Results After three months of supplementation, mean fERG amplitude and fERG sensitivity improved significantly when compared to baseline values (p < 0.01). These changes were stable throughout the follow-up period. No significant differences in clinical and fERG improvements were observed across different CFH or ARMS2 genotypes. Conclusions The present results indicate that the functional effect of Saffron supplementation in individual AMD patients is not related to the major risk genotypes of disease.
- Subjects :
- Male
AMD
Gastroenterology
Macular Degeneration
Polymorphism (computer science)
Risk Factors
Age-related macular degeneration, Saffron, Gene polymorphism, Electroretinography
genetics
Crocus
Aged, 80 and over
Medicine(all)
medicine.diagnostic_test
biology
Settore MED/30 - MALATTIE APPARATO VISIVO
Gene polymorphism
General Medicine
Middle Aged
Saffron
antioxidants
neuroprotection
risk genotype
Factor H
Complement Factor H
Female
medicine.medical_specialty
Heterozygote
Polymorphism, Single Nucleotide
General Biochemistry, Genetics and Molecular Biology
Internal medicine
Ophthalmology
medicine
Electroretinography
Humans
Genetic Predisposition to Disease
Aged
Demography
Plant Extracts
Biochemistry, Genetics and Molecular Biology(all)
Research
Age-related macular degeneration
Proteins
Macular degeneration
medicine.disease
biology.organism_classification
electrophysiology
Age related maculopathy
eye diseases
Age-related maculopathy
Dietary Supplements
Maculopathy
sense organs
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Translational Medicine
- Accession number :
- edsair.doi.dedup.....3354733ab3a89af46a488b71bfffefb6