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Survival following surgical treatment for anorectal melanoma seems similar for local excision and extensive resection regardless of nodal involvement
- Source :
- Surgical oncology-Oxford, 37:101558. ELSEVIER SCI LTD
- Publication Year :
- 2021
- Publisher :
- ELSEVIER SCI LTD, 2021.
-
Abstract
- Background: Anorectal melanoma is a rare malignancy with a dismal prognosis. The purpose of this study was to investigate whether the survival per stage is influenced by the surgical approaches (local excision or extensive resection), to assess prognostic factors of survival, and to answer the question whether the practiced surgical approaches changed over time.Methods: Dutch cancer registry organizations (IKNL and PALGA) were queried for all patients with a diagnosis of anorectal melanoma (1989-2019). Patients with disseminated disease at diagnosis were excluded. Survival outcomes were compared for the two surgical approaches stratified by stage (clinical node negative (cN0) and clinical node positive (cN+)) and date of diagnosis.Results: A total of 103 patients were included in this study. In both cN0 and cN+ patients the surgical strategy did not significantly influence survival (cN0: 21.7% 5-year survival, median 25 months for local excision versus 13.7% 5-year survival, median 17 months for extensive resection (p = 0.228), cN+: 11.1% 5-year survival for local excision, median 17 months versus 8.7% 5-year survival, median 14 months for extensive resection (p = 0.741)). Stage and date of diagnosis showed to be prognostic factors of survival. The ratio between the two surgical approaches was unchanged over three decades.Conclusions: Extensive resection does not seem to improve survival in both cN0 and cN+ anorectal melanoma patients compared to local excision. However in the past three decades no shift towards local excision has been found. cN+ stage and an older date of diagnosis are predictors for worse survival.
- Subjects :
- Male
EXPRESSION
medicine.medical_specialty
Local excision
Staging
Anorectal melanoma
NETHERLANDS
Malignancy
ANTERIOR
Time-to-Treatment
MALIGNANT-MELANOMA
03 medical and health sciences
0302 clinical medicine
QUALITY-OF-LIFE
medicine
Abdominoperineal resection
Humans
Disseminated disease
030212 general & internal medicine
Registries
Stage (cooking)
Melanoma
Aged
Retrospective Studies
Proctectomy
business.industry
KIT MUTATION
MUCOSAL MELANOMAS
Middle Aged
medicine.disease
Anus Neoplasms
SYSTEMIC THERAPY
Surgery
Cancer registry
Survival Rate
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Lymphatic Metastasis
PHASE-II
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 09607404
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- Surgical oncology-Oxford
- Accession number :
- edsair.doi.dedup.....33544802b71bb5ec0d858d1888c296ca