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Virological response to HIV-1 nucleoside/nucleotide reverse transcriptase inhibitors-based, tenofovir DF-including regimens in the ANRS Aquitaine Cohort
- Source :
- Journal of Clinical Virology. 36:95-99
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- HIV-1 nucleoside/tide reverse transcriptase inhibitors (NRTI)-only based, comprising tenofovir DF(TDF) have been shown to lead to high rates of virological failures (VF), mainly in patients on first-line combination therapy. We wished to investigate the virological response to these regimens in a large cohort of antiretroviral (ARV)-treated patients.Patients followed-up in the Aquitaine Cohort in 2001-2003 and who had received NRTI-based, TDF-including regimens for at least 3 months were included. The VF was defined as: (i) a decrease in plasma HIV-1 RNA0.5 log(10)copies/ml between M0 and M3; or (ii) a plasma HIV-1 RNA50 copies/ml at M3 in patients with plasma HIV-1 RNA50 copies/ml at M0. The baseline RT genotype was determined in a subgroup of patients.Within 121 patients (95% ARV-experienced) who received either lamivudine (3TC)/didanosine (DDI)/TDF (n=48), or abacavir (ABC)/3TC/TDF (n=14), or 3TC/zidovudine (ZDV)/TDF (n=27), or 3TC/ZDV/ABC/TDF (n=20), or DDI/ABC/TDF (n=12), the ABC/3TC/TDF and DDI/ABC/TDF combinations were associated with the highest frequencies of VF. In contrast the use of ZDV was related to a better virological response. The baseline RT genotype was also predictive of the virological outcome.NRTI-based, TDF-including therapies can lead to high rates of VF both in ARV-naïve and in ARV-experienced patients. Our data strongly suggest the interest of associating ZDV and TDF in these regimens.
- Subjects :
- Oncology
medicine.medical_specialty
Combination therapy
Organophosphonates
HIV Infections
Biology
Cohort Studies
Hospitals, University
Zidovudine
Species Specificity
immune system diseases
Abacavir
Virology
Internal medicine
medicine
Humans
Tenofovir
Didanosine
Retrospective Studies
Adenine
virus diseases
Lamivudine
Viral Load
biology.organism_classification
Dideoxynucleosides
HIV Reverse Transcriptase
Reverse transcriptase
Treatment Outcome
Infectious Diseases
Mutation
Lentivirus
Cohort
HIV-1
Reverse Transcriptase Inhibitors
Drug Therapy, Combination
France
medicine.drug
Subjects
Details
- ISSN :
- 13866532
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Virology
- Accession number :
- edsair.doi.dedup.....33530b5c46f90e06faa8c694c26de27f