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Early diagnostic test for acute fatty liver of pregnancy: a retrospective case control study
- Source :
- BMC Pregnancy and Childbirth, Vol 20, Iss 1, Pp 1-6 (2020), BMC Pregnancy and Childbirth
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Background Early diagnosis is important to lower the mortality rate of acute fatty liver of pregnancy (AFLP). The Swansea criteria is commonly used to diagnose AFLP, but some terms could only be reached when symptoms and signs have progressed, or are not efficient in clinical practice. Therefore, it is necessary to select cost effective tests to simplify and facilitate early suspicion of acute fatty liver of pregnancy. Methods This is a retrospective study of 28,800 medical records at the Second Xiangya Hospital from 2009 to 2015, including 41 patients with AFLP and 172 other diseases that could show similar symptoms to AFLP. The evaluated variables included past history of liver diseases, blood pressure, gastrointestinal symptoms, blood count, liver function test, coagulation function test and blood sugar test. The sensitivity, specificity, positive predict value and negative predict value were calculated for models in diagnosing AFLP. Results The significant variables associated with AFLP included gastrointestinal symptoms, blood pressure > 140/90 mmHg, aminotransferase> 42 IU/l, total bilirubin> 0.8 mg/dl, total bilirubin acid> 10.0 μmol/L, activated partial prothrombin time(APTT) > 34 s, prothrombin time(PT) > 14 s, white blood cells> 11 *106/l and blood sugar Conclusions Application of a statistical model including maternal symptoms, biochemical and haematological parameters has high diagnostic accuracy for earlier identification of AFLP. However, this finding needs to be tested in another cohort to determine whether this statistical model has the same performance.
- Subjects :
- Adult
medicine.medical_specialty
Bilirubin
Blood sugar
Acute fatty liver of pregnancy
Sensitivity and Specificity
Gastroenterology
lcsh:Gynecology and obstetrics
Bile Acids and Salts
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Liver Function Tests
Pregnancy
Internal medicine
medicine
Humans
lcsh:RG1-991
Retrospective Studies
Prothrombin time
030219 obstetrics & reproductive medicine
medicine.diagnostic_test
business.industry
Case-control study
Obstetrics and Gynecology
Retrospective cohort study
medicine.disease
Early diagnosis
Fatty Liver
Pregnancy Complications
Blood pressure
chemistry
Case-Control Studies
030220 oncology & carcinogenesis
Liver function test
Prothrombin Time
Female
Liver function tests
business
Coagulation function test
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712393
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Pregnancy and Childbirth
- Accession number :
- edsair.doi.dedup.....3352b3c53c8f1b45913a5234a0b25a6b