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Antibodies elicited by SARS-CoV-2 infection or mRNA vaccines have reduced neutralizing activity against Beta and Omicron pseudoviruses
- Source :
- Science translational medicine, vol 14, iss 634, Sci Transl Med
- Publication Year :
- 2022
- Publisher :
- eScholarship, University of California, 2022.
-
Abstract
- Multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants that have mutations associated with increased transmission and antibody escape have arisen over the course of the current pandemic. Although the current vaccines have largely been effective against past variants, the number of mutations found on the Omicron (B.1.1.529) spike protein appear to diminish the protection conferred by preexisting immunity. Using vesicular stomatitis virus (VSV) pseudoparticles expressing the spike protein of several SARS-CoV-2 variants, we evaluated the magnitude and breadth of the neutralizing antibody response over time in individuals after infection and in mRNA-vaccinated individuals. We observed that boosting increases the magnitude of the antibody response to wild-type (D614), Beta, Delta, and Omicron variants; however, the Omicron variant was the most resistant to neutralization. We further observed that vaccinated healthy adults had robust and broad antibody responses, whereas responses may have been reduced in vaccinated pregnant women, underscoring the importance of learning how to maximize mRNA vaccine responses in pregnant populations. Findings from this study show substantial heterogeneity in the magnitude and breadth of responses after infection and mRNA vaccination and may support the addition of more conserved viral antigens to existing SARS-CoV-2 vaccines.
- Subjects :
- Adult
and promotion of well-being
COVID-19 Vaccines
Antibodies, Viral
Medical and Health Sciences
Article
Antibodies
Vaccine Related
Pregnancy
Clinical Research
Biodefense
Humans
Viral
Pregnancy Complications, Infectious
Neutralizing
Lung
Vaccines, Synthetic
Vaccines
SARS-CoV-2
Prevention
Synthetic
Infectious
COVID-19
General Medicine
Pneumonia
Biological Sciences
Prevention of disease and conditions
Antibodies, Neutralizing
Spike Glycoprotein
Pregnancy Complications
Coronavirus
Infectious Diseases
Emerging Infectious Diseases
Good Health and Well Being
3.4 Vaccines
Spike Glycoprotein, Coronavirus
Pneumonia & Influenza
Female
Immunization
mRNA Vaccines
Infection
Biotechnology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Science translational medicine, vol 14, iss 634, Sci Transl Med
- Accession number :
- edsair.doi.dedup.....334fda2360b0c1bb8ad6398ec7212da7