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Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities
- Source :
- Journal of neurochemistry 107 (2008): 1047–1055. doi:10.1111/j.1471-4159.2008.05656.x, info:cnr-pdr/source/autori:Geraci, C.; Merlo, S.; Sortino, M. A.; Drago, F.; Viola, S.; Consoli, G. M. L./titolo:Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities/doi:10.1111%2Fj.1471-4159.2008.05656.x/rivista:Journal of neurochemistry/anno:2008/pagina_da:1047/pagina_a:1055/intervallo_pagine:1047–1055/volume:107, info:cnr-pdr/source/autori:Viola S.; Consoli G. M. L.; Merlo S.; Drago F.; Sortino M. A.; Geraci C./titolo:Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities/doi:10.1111%2Fj.1471-4159.2008.05656.x/rivista:Journal of neurochemistry/anno:2008/pagina_da:1047/pagina_a:1055/intervallo_pagine:1047–1055/volume:107
- Publication Year :
- 2008
-
Abstract
- b1,4-Galactosyltransferases (b1,4-GalTase) exposed on the cell surface are involved in cell migration. Specifically, b1,4-GalTase V is highly expressed in glioma and promotes invasion, growth, and survival of glioma cells. A glycocalix[8]arene exposing N-acetylglucosamine (GlcNAc) residues (compound1) inhibi ma cell migration as assessed in a scratch wound model. This effect was related to inhibition of focal adhesion kinase phosphorylation, measured by western blot analysis, and specifically observed in the area bordering the scratch wound. Compound 1 inhibited also C6 cell proliferation, an effect unrelated to its ability to interact with Gal-Tase as it was mimicked by different calix[8]arene derivatives, all characterized by multivalency and ureido groups. Compound 1 did not induce apoptotic death, but caused a different distribution of C6 cells within the cell cycle. The results here reported identify compound 1 as a molecule able to exert inhibitory effects on C6 cell migration and proliferation, independently, because of distinct components in its structure. Keywords: adhesion molecule, calixarene glycoconjugate, cell growth, galactosyl transferase.
- Subjects :
- Time Factors
Cell
Tetrazolium Salts
Cyclopentanes
Biology
Biochemistry
Focal adhesion
Cellular and Molecular Neuroscience
Western blot
Cell Movement
Glioma
Cell Line, Tumor
medicine
cell growth
Animals
glycoconjugate
Cell Proliferation
Analysis of Variance
medicine.diagnostic_test
Cell growth
Cell Cycle
Cell cycle
medicine.disease
adhesion molecule
Cell biology
Rats
Enzyme Activation
Thiazoles
medicine.anatomical_structure
Bromodeoxyuridine
Cell culture
Focal Adhesion Kinase 1
calixarene
Phosphorylation
N-Acetylgalactosaminyltransferases
Wounds and Injuries
Benzimidazoles
Calixarenes
galactosyl transferase
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of neurochemistry 107 (2008): 1047–1055. doi:10.1111/j.1471-4159.2008.05656.x, info:cnr-pdr/source/autori:Geraci, C.; Merlo, S.; Sortino, M. A.; Drago, F.; Viola, S.; Consoli, G. M. L./titolo:Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities/doi:10.1111%2Fj.1471-4159.2008.05656.x/rivista:Journal of neurochemistry/anno:2008/pagina_da:1047/pagina_a:1055/intervallo_pagine:1047–1055/volume:107, info:cnr-pdr/source/autori:Viola S.; Consoli G. M. L.; Merlo S.; Drago F.; Sortino M. A.; Geraci C./titolo:Inhibition of rat glioma cell migration and proliferation by a calix[8]arene scaffold exposing multiple GlcNAc and ureido functionalities/doi:10.1111%2Fj.1471-4159.2008.05656.x/rivista:Journal of neurochemistry/anno:2008/pagina_da:1047/pagina_a:1055/intervallo_pagine:1047–1055/volume:107
- Accession number :
- edsair.doi.dedup.....3342c66fd15381ba5dd3b2083e9168f9