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Transdermal Delivery Systems for Ibuprofen and Ibuprofen Modified with Amino Acids Alkyl Esters Based on Bacterial Cellulose
- Source :
- International Journal of Molecular Sciences, Volume 22, Issue 12, International Journal of Molecular Sciences, Vol 22, Iss 6252, p 6252 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- The potential of bacterial cellulose as a carrier for the transport of ibuprofen (a typical example of non-steroidal anti-inflammatory drugs) through the skin was investigated. Ibuprofen and its amino acid ester salts-loaded BC membranes were prepared through a simple methodology and characterized in terms of structure and morphology. Two salts of amino acid isopropyl esters were used in the research, namely L-valine isopropyl ester ibuprofenate ([ValOiPr][IBU]) and L-leucine isopropyl ester ibuprofenate ([LeuOiPr][IBU]). [LeuOiPr][IBU] is a new compound<br />therefore, it has been fully characterized and its identity confirmed. For all membranes obtained the surface morphology, tensile mechanical properties, active compound dissolution assays, and permeation and skin accumulation studies of API (active pharmaceutical ingredient) were determined. The obtained membranes were very homogeneous. In vitro diffusion studies with Franz cells were conducted using pig epidermal membranes, and showed that the incorporation of ibuprofen in BC membranes provided lower permeation rates to those obtained with amino acids ester salts of ibuprofen. This release profile together with the ease of application and the simple preparation and assembly of the drug-loaded membranes indicates the enormous potentialities of using BC membranes for transdermal application of ibuprofen in the form of amino acid ester salts.
- Subjects :
- Swine
02 engineering and technology
01 natural sciences
chemistry.chemical_compound
Drug Delivery Systems
Organic chemistry
Biology (General)
Amino Acids
Spectroscopy
Skin
Transdermal
ibuprofen
Active ingredient
chemistry.chemical_classification
Chemistry
bacterial cellulose
Anti-Inflammatory Agents, Non-Steroidal
Esters
General Medicine
Permeation
021001 nanoscience & nanotechnology
Ibuprofen
transdermal drug delivery
Computer Science Applications
Amino acid
Membrane
Bacterial cellulose
0210 nano-technology
amino acid
medicine.drug
QH301-705.5
Skin Absorption
Administration, Cutaneous
010402 general chemistry
Article
Catalysis
Inorganic Chemistry
non-steroidal anti-inflammatory drug
medicine
Animals
skin barrier
Physical and Theoretical Chemistry
Cellulose
QD1-999
Molecular Biology
Bacteria
organic chemicals
Organic Chemistry
0104 chemical sciences
Isopropyl
Subjects
Details
- Language :
- English
- ISSN :
- 14220067
- Database :
- OpenAIRE
- Journal :
- International Journal of Molecular Sciences
- Accession number :
- edsair.doi.dedup.....333ffa9ec62862218318924b180c40f6
- Full Text :
- https://doi.org/10.3390/ijms22126252