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Copper-Catalyzed Oxidative Cyclization of Maleimides with Amines and Alkyne Esters: Direct Access to Fully Substituted Dihydropyrroles and Pyrrole Derivatives
- Source :
- Organic Letters. 19:6044-6047
- Publication Year :
- 2017
- Publisher :
- American Chemical Society (ACS), 2017.
-
Abstract
- An efficient and practical Cu(I)-catalyzed oxidative cyclization cascade reaction of diverse amines, alkyne esters and maleimides has been developed. The reactions can afford 4,6-dioxopyrrolo[3,4-b]pyrrole-2,3-dicarboxylates and related derivatives with satisfactory yields by altering the reaction conditions slightly. The substrate scope highlights the flexibility of the catalyst, and a reaction mechanism is also proposed.
- Subjects :
- chemistry.chemical_classification
Oxidative cyclization
Reaction mechanism
010405 organic chemistry
Chemistry
Organic Chemistry
Substrate (chemistry)
Alkyne
010402 general chemistry
01 natural sciences
Biochemistry
Pyrrole derivatives
0104 chemical sciences
Catalysis
Cascade reaction
Copper catalyzed
Organic chemistry
Physical and Theoretical Chemistry
Subjects
Details
- ISSN :
- 15237052 and 15237060
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Organic Letters
- Accession number :
- edsair.doi.dedup.....3330f5cbd1cf95acdd079a5a345fcf20